Evidence map›Paper›PMID 29924476›Full record

ArticlePhysiological reports2018

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes.

Rugivan Sabaratnam, Andreas J T Pedersen, Jonas M Kristensen, Aase Handberg, Jørgen F P Wojtaszewski, Kurt Højlund

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06680713 (Effects of a Single Maximal Exercise Session on the Metabolic Function of Physically Inactive Young Adults), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06680713 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of a Single Maximal Exercise Session on the Metabolic Function of Physically Inactive Young Adults

TypeinterventionalSponsorSergio Martinez-HuenchullanRan2024 to 2024Enrolled22ConditionsPhysical DeconditioningArmsExercise
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  15. Plasma Proteomic Kinetics in Response to Acute Exercise.Molecular & cellular proteomics : MCP · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Rugivan SabaratnamSection of Molecular Diabetes & Metabolism, Institute of Clinical Research, Institute of Molecular Medicine, University of Southern Denmark, Odense C, Denmark.
Andreas J T PedersenDepartment of Endocrinology, Odense University Hospital, Odense C, Denmark.
Jonas M KristensenSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Aase HandbergDepartment of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
Jørgen F P WojtaszewskiSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Kurt HøjlundSection of Molecular Diabetes & Metabolism, Institute of Clinical Research, Institute of Molecular Medicine, University of Southern Denmark, Odense C, Denmark.
Odense University Hospital · DKUniversity of Copenhagen · DKAalborg University · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular exercise plays an important role in the prevention and treatment of type 2 diabetes (T2D). The synthesis and secretion of myokines in response to contraction may contribute to the beneficial metabolic effects of exercise. However, some exercise-induced responses may be attenuated in T2D. Here, we investigated whether the effect of acute exercise on selected myokines are impaired in T2D. Skeletal muscle biopsies and blood samples were obtained from 13 men with T2D and 14 weight-matched, glucose-tolerant men before, immediately after and 3-h after acute exercise (60 min cycling) to examine muscle expression and plasma/serum levels of selected myokines. One-hour of exercise increased muscle expression of IL6, FGF21, ANGPTL4, CHI3L1, CTGF and CYR61, of which FGF21, ANGPTL4 and CHI3L1 increased further 3-h into recovery, whereas expression of IL6, CYR61, and CTGF returned to baseline levels. There was no immediate effect of exercise on IL15 expression, but it decreased 3-h into recovery. Plasma IL-6 increased robustly, whereas circulating levels of FGF21, ANGPTL4, IL-15, and CHI3L1 increased only modestly in response to exercise. All returned toward baseline levels 3-h into recovery except for plasma ANGPTL4, which increased further. No significant differences in these responses to exercise were observed between the groups. Our results demonstrate that muscle expression and circulating levels of selected known and putative myokines were equally regulated by acute exercise in patients with T2D and weight-matched controls. This suggests that the potential beneficial metabolic effects of these myokines are not impaired in patients with T2D.

Indexed as

Angiopoietin-Like Protein 4Case-Control StudiesChitinase-3-Like Protein 1Connective Tissue Growth FactorCysteine-Rich Protein 61CytokinesDiabetes Mellitus, Type 2ExerciseFibroblast Growth FactorsGene Expression RegulationHumansInterleukin-15Interleukin-6MaleMiddle AgedMuscle ProteinsAngiopoietin-Like Protein 4ANGPTL4 protein, humanCCN1 protein, humanCCN2 protein, humanCHI3L1 protein, humanChitinase-3-Like Protein 1Connective Tissue Growth FactorCysteine-Rich Protein 61Cytokinesfibroblast growth factor 21Fibroblast Growth FactorsIL15 protein, humanIL6 protein, humanInterleukin-15Interleukin-6Muscle ProteinsExercise resistancemyokinesskeletal muscleT2D

Identifiers

PMID29924476
PMCPMC6009776
OpenAlexW2809674613

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.