Evidence map›Paper›PMID 29924462›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2018

Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse.

Michael P Triebwasser, Xiaobo Wu, Paula Bertram, Dennis E Hourcade, Donald Michael Nelson, John P Atkinson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michael P TriebwasserDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.
Xiaobo WuDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.
Paula BertramDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.
Dennis E HourcadeDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.
Donald Michael NelsonDepartment of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Ultrasound and Genetics, Washington University School of Medicine, St. Louis, MO, USA.
John P AtkinsonDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2514-3441
Washington University in St. Louis · US

Funding

Viral Discovery in Rheumatoid ArthritisP30AR048335 · NIAMS · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S · 2001 to 2015
$8.9M
Complement Receptor One (CRI): Structure/FunctionR01AI041592 · NIAID · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 1997 to 2013
$3.9M
COMPLEMENT CONVERTASE: ASSEMBLY, FUNCTION AND REGULATIONR01AI051436 · NIAID · WASHINGTON UNIVERSITY · PI HOURCADE, DENNIS EMIL · 2003 to 2016
$3.7M
INTRACELLULAR C3 PROTEINS: SOURCE, COMPOSITION, TRAFFICKING AND FUNCTIONR01GM099111 · NIGMS · WASHINGTON UNIVERSITY · PI ATKINSON, JOHN · 2011 to 2019
$2.7M
The Role of Complement in the Pathogenesis of PreeclampsiaF30HL103072 · NHLBI · WASHINGTON UNIVERSITY · PI TRIEBWASSER, MICHAEL PAUL · 2010 to 2013
$147k
NHLBI NIH HHS F30 HL103072NIAID NIH HHS R01 AI041592NIAID NIH HHS R01 AI051436NIAMS NIH HHS P30 AR048335NIGMS NIH HHS R01 GM099111
6 · The paper itself

Abstract

problemCrry is a widely expressed type 1 transmembrane complement regulatory protein in rodents which protects self-tissue by downregulating C3 activation. Crry METHOD OF STUDY: We investigated the basis of Crry

resultsWe narrowed the critical period of the complement effect from 6.5 to 8.5 days post-coitus (dpc), which is immediately after the conceptus is exposed to maternal blood. Deposition by 5.5 dpc of maternal C3b on the placental vasculature lacking Crry

conclusionOur data are most consistent with the deposition of C3b being responsible for the failure of the allantois to fuse to the chorion leading to subsequent conceptus demise.

Indexed as

Abortion, SpontaneousAnimalsComplement ActivationComplement C3bComplement C3-C5 Convertases, Alternative PathwayComplement Pathway, AlternativeEmbryo, MammalianFemaleMiceMice, KnockoutPlacentaPregnancyReceptors, ComplementReceptors, Complement 3bComplement C3bComplement C3-C5 Convertases, Alternative PathwayCr1l protein, mouseReceptors, ComplementReceptors, Complement 3balternative pathwayC3b depositioncomplement membrane regulatory activity deficiencycomplement systemconceptus demiseCrryfusion of the allantois to the chorion

Identifiers

PMID29924462
PMCPMC6160323
OpenAlexW2809524758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.