Evidence map›Paper›PMID 29924461›Full record

Trial reportEuropean journal of neurology2018

Short-term external counterpulsation augments cerebral blood flow and tissue oxygenation in chronic cerebrovascular occlusive disease.

E E Buschmann, P Hillmeister, A Bondke Persson, D S Liebeskind, L Schlich, R Kamenzky, A Busjahn, I R Buschmann, P Bramlage, A Hetzel and 1 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

E E BuschmannDepartment for Cardiology, Center of Internal Medicine, Medical University Graz, Graz, Austria.
P HillmeisterBrandenburg School of Medicine, Center for Internal Medicine I, Department for Angiology, Brandenburg an der Havel, Germany.
A Bondke PerssonInstitute of Vegetative Physiology, Charité Universitaetsmedizin Berlin, Berlin, Germany.
D S LiebeskindNeurovascular Imaging Research Core and UCLA Stroke Center, Los Angeles, CA, USA.
L SchlichDepartment of Neurology, University of Freiburg, Freiburg, Germany.
R KamenzkyDepartment of Cardiology, Charité Universitaetsmedizin Berlin, Campus Virchow, Berlin, Germany.
A BusjahnHealthTwiSt GmbH, Berlin, Germany.
I R BuschmannBrandenburg School of Medicine, Center for Internal Medicine I, Department for Angiology, Brandenburg an der Havel, Germany.
P BramlageBrandenburg School of Medicine, Center for Internal Medicine I, Department for Angiology, Brandenburg an der Havel, Germany.ORCID 0000-0003-4970-2110
A HetzelSchwarzwaldklinik Neurologie, Bad Krozingen, Germany.
M ReinhardDepartment of Neurology, University of Freiburg, Freiburg, Germany.
Charité - Universitätsmedizin Berlin · DEUniversitätsklinikum Brandenburg an der Havel · DEUniversity of Freiburg · DEIPPMed (Germany) · DEMedical University of Graz · ATSchwarzwald-Baar Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeExternal counterpulsation improves cerebral perfusion velocity in acute stroke and may stimulate collateral artery growth. However, whether (non-acute) at-risk patients with high-grade carotid artery disease may benefit from counterpulsation needs to be validated.

methodsTwenty-eight patients (71 ± 6.5 years, five women) with asymptomatic unilateral chronic severe internal carotid artery stenosis (>70%) or occlusion were randomized to receive 20 min active counterpulsation followed by sham treatment or vice versa. Cerebral blood flow velocity (CBFV) (measured bilaterally by transcranial middle cerebral artery Doppler), tissue oxygenation index (TOI) (measured over the bilateral prefrontal cortex by near-infrared spectroscopy) and cerebral hemodynamic parameters, such as relative pulse slope index (RPSI), were monitored.

resultsIpsilateral mean CBFV (ΔV

conclusionsIn patients with high-grade carotid disease, ipsilateral cerebral oxygenation and blood flow velocity are increased by counterpulsation. This is a necessary condition for the stimulation of regenerative collateral artery growth and thus a therapeutic concept for the prevention of cerebral ischaemia. This study provides a rationale for further clinical investigations on the long-term effects of counterpulsation on cerebral hemodynamics and collateral growth.

Indexed as

CounterpulsationAgedBlood Flow VelocityCerebrovascular CirculationCerebrovascular DisordersFemaleHemodynamicsHumansMaleMiddle AgedMiddle Cerebral ArteryUltrasonography, Doppler, Transcranialarteriogenesiscarotid arterycerebral hemodynamicscerebrovascular diseaseexternal counterpulsation

Identifiers

PMID29924461
PMCPMC6221180
OpenAlexW2808848761

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.