Evidence map›Paper›PMID 29924436›Full record

ArticleHelicobacter2018

Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance.

Kosuke Sakitani, Toshihiro Nishizawa, Masahide Arita, Shuntaro Yoshida, Yosuke Kataoka, Daisuke Ohki, Hiroharu Yamashita, Yoshihiro Isomura, Akira Toyoshima, Hidenobu Watanabe and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Helicobacter, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Helicobacter pylori Management in Older Adults: Current Perspectives From Japan.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Review
  2. Gastritis: Pathophysiology, Diagnosis, and Clinical Implications.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Review
  3. Article
  4. Clinical and endoscopic features of metachronous gastric cancer with possible lymph node metastasis after endoscopic submucosal dissection and Helicobacter pylori eradication.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023
    Article
  5. The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023
    Article
  6. Review
  7. Increasing trend ofJournal of clinical biochemistry and nutrition · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. A single nucleotide polymorphism inJournal of clinical biochemistry and nutrition · 2021
    Article
  13. Article
  14. Article
  15. JGH open : an open access journal of gastroenterology and hepatology · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Burden of Gastroduodenal Diseases from the Global Perspective.Current treatment options in gastroenterology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Kosuke SakitaniDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4537-6023
Toshihiro NishizawaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
Masahide AritaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
Shuntaro YoshidaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
Yosuke KataokaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
Daisuke OhkiDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
Hiroharu YamashitaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
Yoshihiro IsomuraDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
Akira ToyoshimaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
Hidenobu WatanabeDepartment of Pathology, PCL Japan, Tokyo, Japan.
Toshiro IizukaDepartment of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
Yutaka SaitoEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Junko FujisakiDepartment of Gastroenterology, Cancer Institute Hospital, Tokyo, Japan.
Naohisa YahagiDivision of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan.
Kazuhiko KoikeDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Osamu ToyoshimaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6953-6079
National Sanatorium Ooshima Seishōen · JPJapan Lifeline (Japan) · JPKeio University · JPNational Cancer Center Hospital East · JPThe Cancer Institute Hospital · JPThe University of Tokyo · JPToranomon Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHelicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy. MATERIALS AND

methodsAll-cause death rates and gastric cancer-specific death rates in gastric cancer patients who received successful H. pylori eradication treatment was tracked and compared to rates in patients who did not receive successful eradication therapy.

resultsIn total, 160 gastric cancer patients were followed-up for up to 11.7 years (mean 3.5 years). Among them, 53 gastric cancer patients received successful H. pylori eradication therapy prior to gastric cancer diagnosis. During the follow-up period, 11 all-cause deaths occurred. In the successful eradication group, the proportion of patients with cancer stage I was higher. The proportions of patients who received curative endoscopic therapy and endoscopic examination in the 2 years prior to gastric cancer diagnosis were also higher in the successful eradication group. Kaplan-Meier analysis of all-cause death and gastric cancer-specific death revealed a lower death rate in patients in the successful eradication group (P = .0139, and P = .0396, respectively, log-rank test). The multivariate analysis showed that endoscopy within 2 years before cancer diagnosis is associated with stage I cancer.

conclusionsPossible early discovery of gastric cancer after H. pylori eradication due to regular endoscopic surveillance may contribute to better prognosis of patients with gastric cancer.

Indexed as

AdultAgedAged, 80 and overAnti-Bacterial AgentsEarly Detection of CancerFemaleFollow-Up StudiesGastroscopyHelicobacter InfectionsHelicobacter pyloriHumansKaplan-Meier EstimateMaleMiddle AgedRetrospective StudiesStomach NeoplasmsAnti-Bacterial Agentsendoscopic surveillancegastric cancerH. pylori eradicationmortality rate

Identifiers

PMID29924436
PMCPMC6055630
OpenAlexW2809160911

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.