Evidence map›Paper›PMID 29924318›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019

Is Who you Ask Important? Concordance Between Survey and Registry Data on Medication Use Among Self- and Proxy-Respondents in the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study.

Anna Oksuzyan, Torsten Sauer, Jutta Gampe, Andreas Höhn, Mette Wod, Kaare Christensen, Jonas W Wastesson

Open access · hybridAbstract readTwin Study
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Anna OksuzyanMax Planck Institute for Demographic Research, Rostock, Germany.
Torsten SauerMax Planck Institute for Demographic Research, Rostock, Germany.
Jutta GampeMax Planck Institute for Demographic Research, Rostock, Germany.
Andreas HöhnMax Planck Institute for Demographic Research, Rostock, Germany.
Mette WodDepartment of Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense.
Kaare ChristensenDepartment of Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense.
Jonas W WastessonAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institute and Stockholm University, Sweden.
University of Southern Denmark · DKMax Planck Institute for Demographic Research · DEStockholm University · SEUniversity of Rostock · DE

Funding

THE RANGE OF MALE-FEMALE MORTALITY DIFFERENCESP01AG031719 · NIA · DUKE UNIVERSITY · PI ZENG, YI · 2009 to 2020
$10.2M
Biodemography of Disease and Death in MoscowR01AG026786 · NIA · DUKE UNIVERSITY · PI VAUPEL, JAMES W. · 2006 to 2010
$1.9M
NIA NIH HHS P01 AG031719NIA NIH HHS R01 AG026786
6 · The paper itself

Abstract

backgroundThis study investigates the accuracy of the reporting of medication use by proxy- and self-respondents, and it compares the prognostic value of the number of medications from survey and registry data for predicting mortality across self- and proxy-respondents.

methodsThe study is based on the linkage of the Longitudinal Study of Aging Danish Twins and the Danish 1905-Cohort Study with the Danish National Prescription Registry. We investigated the concordance between survey and registry data, and the prognostic value of medication use when assessed using survey and registry data, to predict mortality for self- and proxy-respondents at intake surveys.

resultsAmong self-respondents, the agreement was moderate (κ = 0.52-0.58) for most therapeutic groups, whereas among proxy-respondents, the agreement was low to moderate (κ = 0.36-0.60). The magnitude of the relative differences was, generally, greater among proxies than among self-respondents. Each additional increase in the total number of medications was associated with 7%-8% mortality increase among self- and 4%-6% mortality increase among proxy-respondents in both the survey and registry data. The predictive value of the total number of medications estimated from either data source was lower among proxies (c-statistic = 0.56-0.58) than among self-respondents (c-statistic = 0.74).

conclusionsThe concordance between survey and registry data regarding medication use and the predictive value of the number of medications for mortality were lower among proxy- than among self-respondents.

Indexed as

Drug TherapyRegistriesSurveys and QuestionnairesDenmarkFemaleHumansLongitudinal StudiesMaleMortalityPrognosisProxyReproducibility of ResultsSelf ReportDenmarkMedication useProxyRegister studySelf-respondents

Identifiers

PMID29924318
PMCPMC6477639
OpenAlexW2809216407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.