ArticleClinics (Sao Paulo, Brazil)2018
Evaluation of systemic inflammation in patients being weaned from mechanical ventilation.
Article in Clinics (Sao Paulo, Brazil), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Electrical Impedance Tomography-Guided Airway Clearance in Elderly Patients With Severe Pneumonia: A Prospective Study.The clinical respiratory journal · 2025Trial
- Effects of Phrenic Nerve Stimulation in Mechanically Ventilated Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Inflammatory Cytokines as Early Predictors of Weaning Failure From Extracorporeal Life Support.Artificial organs · 2026Article
- Early invasive mechanical ventilation improves 28-day clinical outcomes in patients with severe pneumonia complicated by gastrointestinal dysfunction.American journal of translational research · 2025Article
- Predicting Successful Weaning through Sonographic Measurement of the Rapid Shallow Breathing Index.Journal of clinical medicine · 2024Article
- Association of biomarkers with successful ventilatory weaning in COVID-19 patients: an observational study.Critical care science · 2024Observational
- Exogenous surfactant reduces inflammation and redox imbalance in rats under prone or supine mechanical ventilation.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Weaning Failure in Critically Ill Patients Is Related to the Persistence of Sepsis Inflammation.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test.
methodsThis cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1β, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFα) and C-reactive protein.
resultsPatients who experienced extubation failure presented a lower rapid shallow breathing index than those who passed, and these patients also showed a significant increase in C-reactive protein 48 hours after extubation. We observed, moreover, that each unit increase in inflammatory factors led to a higher risk of spontaneous ventilation test failure, with a risk of 2.27 (1.001 - 4.60, p=0.049) for TNFα, 2.23 (1.06 - 6.54, p=0.037) for IL-6, 2.66 (1.06 - 6.70, p=0.037) for IL-8 and 2.08 (1.01 - 4.31, p=0.04) for IL-10, and the rapid shallow breathing index was correlated with IL-1 (r=-0.51, p=0.04).
conclusionsC-reactive protein is increased in patients who fail the spontaneous ventilation test, and increased ILs are associated with a greater prevalence of failure in this process; the rapid shallow breathing index may not be effective in patients who present systemic inflammation.
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