Evidence map›Paper›PMID 29923902›Full record

ArticleAdvances in skin & wound care2018

Changes in S100 Proteins Identified in Healthy Skin following Electrical Stimulation: Relevance for Wound Healing.

Chloe Lallyett, Ching-Yan Chloé Yeung, Rie Harboe Nielson, Leo A H Zeef, David Chapman-Jones, Michael Kjaer, Karl E Kadler

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In one paragraph

Article in Advances in skin & wound care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Electric Factors in Wound Healing.Advances in wound care · 2021
    Article
  4. Article
  5. Effects of electrical stimulation on skin surface.Acta mechanica Sinica = Li xue xue bao · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chloe LallyettChloe Lallyett, PhD, is a Science Teacher, Parrs Wood High School, Manchester, United Kingdom; Ching-Yan Chloé Yeung, PhD, is a Postdoctorate Fellow, Institute of Sports Medicine Copenhagen, Denmark; Rie Harboe Nielson, MD, PhD, is a Physician, Department of Rheumatology, Aarhus University Hospital, Denmark; Leo A. H. Zeef, PhD, is Experimental Officer, University of Manchester, United Kingdom; David Chapman-Jones, LLM(Med), PhD, is Professor of Healthcare and Director, Institute of Healthcare Policy and Practice, University of the West of Scotland, United Kingdom; Michael Kjaer, MD, PhD, is Professor of Sports Medicine, University of Copenhagen, Denmark; and Karl E. Kadler, PhD, is Professor of Biochemistry, University of Manchester, United Kingdom.
Ching-Yan Chloé Yeung
Rie Harboe Nielson
Leo A H Zeef
David Chapman-Jones
Michael Kjaer
Karl E Kadler
Copenhagen University Hospital · DK

Funding

Wellcome Trust 110126/Z/15/ZWellcome Trust 203128
6 · The paper itself

Abstract

objectiveTargeted electrical energy applied to wounds has been shown to improve wound-healing rates. However, the mechanisms are poorly understood. The aim of this study was to identify genes that are responsive to electrical stimulation (ES) in healthy subjects with undamaged skin.

methodsTo achieve this objective, study authors used a small, noninvasive ES medical device to deliver a continuous, specific, set sequence of electrical energy impulses over a 48-hour period to the skin of healthy volunteers and compared resultant gene expression by microarray analysis. MAIN

resultsApplication of this specific ES resulted in differential expression of 105 genes, the majority of which were down-regulated. Postmicroarray analyses revealed there was commonality with a small number of genes that have previously been shown to be up-regulated in skin wounds, including venous leg ulcers.

conclusionsThe specific sequence of ES applied continuously for 48 hours to the skin of healthy patients has the effect of modifying expression in a number of identified genes. The identification of the differential expression in this subset of genes in healthy subjects provides new potential lines of scientific inquiry for identifying similar responses in subjects with slow or poorly healing wounds.

Indexed as

Electric StimulationHealthy VolunteersHumansS100 ProteinsSkinWound HealingS100 Proteins

Identifiers

PMID29923902
PMCPMC7613302
OpenAlexW2809548958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.