Evidence map›Paper›PMID 29923883›Full record

ArticleEye & contact lens2018

Axial Elongation in Myopic Children and its Association With Myopia Progression in the Correction of Myopia Evaluation Trial.

Wei Hou, Thomas T Norton, Leslie Hyman, Jane Gwiazda, COMET Group

Open access · greenAbstract read
In one paragraph

Article in Eye & contact lens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Axial length targets for myopia control.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2021
    Trial
  5. Combination therapy for myopia control using defocus incorporated multiple segments spectacles in children refractory to higher-dose atropine.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Identifying and Managing Pre-Myopia: A Narrative Review.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Review
  11. Review
  12. Article
  13. The prevalence and costs of optical correction for childhood myopia in Scotland.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
  14. Axial length as a function of age, sex, and ethnicity: Results from the CLEERE study.Optometry and vision science : official publication of the American Academy of Optometry · 2025
    Article
  15. Can fundus features tell us something about 3D eye shape?Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Wei HouDepartment of Family, Population and Preventive Medicine (W.H.), Stony Brook University, Stony Brook, NY; Department of Optometry and Vision Science (T.T.N.), School of Optometry, University of Alabama at Birmingham, Birmingham, AL; Wills Eye Hospital (L.H.), Ophthalmology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA; and New England College of Optometry (J.G.), Boston, MA.
Thomas T Norton
Leslie Hyman
Jane Gwiazda
COMET Group
New England College of Optometry · USUniversity Medical Center · USUniversity of Alabama at Birmingham · USWills Eye Hospital · US

Funding

EVALUATION TRIAL--COORDINATING CENTERU10EY011805 · NEI · STATE UNIVERSITY NEW YORK STONY BROOK · PI HYMAN, LESLIE G · 1996 to 2013
$9.4M
CORRECTION OF MYOPIA TRIAL--CLINICAL CENTERU10EY011740 · NEI · UNIVERSITY OF HOUSTON · PI MANNY, RUTH E · 1997 to 2013
$2.8M
CORRECTION OF MYOPIA EVALUATION TRIAL (COMET)U10EY011755 · NEI · SALUS UNIVERSITY · PI SCHEIMAN, MITCHELL M · 1997 to 2013
$2.6M
CORRECTION OF MYOPIA EVALUATION TRIAL--CHAIR PHASE IIU10EY011756 · NEI · NEW ENGLAND COLLEGE OF OPTOMETRY · PI GWIAZDA, JANE E. · 1997 to 2013
$2.1M
NEI NIH HHS U10 EY011740NEI NIH HHS U10 EY011755NEI NIH HHS U10 EY011756NEI NIH HHS U10 EY011805
6 · The paper itself

Abstract

objectivesDescribe axial elongation using 14-year longitudinal data in a large, ethnically diverse group of myopic children, estimate age and axial length (AL) at stabilization, and evaluate associations between the progression and stabilization of AL and myopia.

methodsAxial length was measured by A-scan ultrasonography annually. Axial length data were fit with individual polynomial functions and curve-based parameters (AL at stabilization and age at stabilization when annual rate of axial elongation ≤0.06 mm) were estimated. For myopia progression, noncycloplegic spherical equivalent refractions were fit with Gompertz functions.

resultsFour hundred thirty-one participants, with AL and myopia data fit successfully, were classified into four cohorts: Younger (n=30); Older (n=334); AL Stabilized at Baseline (n=19); and AL Not Stabilized (n=48). At AL stabilization, for participants in the Younger and Older Cohorts, mean (SD) age and AL were 16.3 (2.4) years and 25.2 (0.9) mm, respectively. No associations were found between age at AL stabilization and ethnicity, sex, or number of myopic parents. At stabilization, sex and number of myopic parents (both P<0.003), but not ethnicity, were significantly associated with AL. Axial length and myopia progression curves were highly correlated overall (all r>0.77, P<0.0001). However, unlike AL, the amount of myopia did not differ significantly between males and females.

conclusionsIn most of the participants, AL increased rapidly at younger ages and then slowed and stabilized. The close association between growth and stabilization of AL and myopia is consistent with the suggestion that axial elongation is the primary ocular component in myopia progression and stabilization.

Indexed as

EyeglassesAge FactorsAnalysis of VarianceAxial Length, EyeChildDisease ProgressionHumansLongitudinal StudiesMyopiaRefraction, OcularRisk FactorsSex Factors

Identifiers

PMID29923883
PMCPMC6013843
OpenAlexW2809257451

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.