ArticlePhysics in medicine and biology2018
Photoacoustic imaging of a human vertebra: implications for guiding spinal fusion surgeries.
Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- Real-time photoacoustic imaging with freehand light delivery and augmented reality guidance.Photoacoustics · 2026Article
- In Vivo Demonstration of Deep Learning-Based Photoacoustic Visual Servoing System.IEEE transactions on bio-medical engineering · 2026Article
- Photoacoustic imaging combined with robotics: a review of current works.Biomedical optics express · 2025Review
- Intraosseous ultrasound for assessment of pedicle screw holes in the thoracolumbar spine based on endoscopic ultrasound: An experimental study.Acta neurochirurgica · 2025Article
- Advances in imaging modalities for spinal tumors.Neuro-oncology advances · 2024Review
- Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.Photoacoustics · 2023Review
- Flexible array transducer for photoacoustic-guided interventions: phantom andBiomedical optics express · 2023Article
- Diffuse reflectance spectroscopy of the spine: improved breach detection with angulated fibers.Biomedical optics express · 2023Article
- Recent advances in aggregation-induced emission luminogens in photoacoustic imaging.European journal of nuclear medicine and molecular imaging · 2022Review
- Perspective on the integration of optical sensing into orthopedic surgical devices.Journal of biomedical optics · 2022Article
- A photoacoustics-enhanced drilling probe for radiation-free pedicle screw implantation in spinal surgery.Frontiers in bioengineering and biotechnology · 2022Article
- Image-guided surgery and novel intraoperative devices for enhanced visualisation in general and paediatric surgery: a review.Innovative surgical sciences · 2021Review
- Combined Ultrasound and Photoacoustic Image Guidance of Spinal Pedicle Cannulation Demonstrated With Intact ex vivo Specimens.IEEE transactions on bio-medical engineering · 2021Article
- Photoacoustic-guided surgery from head to toe [Invited].Biomedical optics express · 2021Review
- Empirical assessment of laser safety for photoacoustic-guided liver surgeries.Biomedical optics express · 2021Article
- Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights.Frontiers in bioengineering and biotechnology · 2021Review
- Comparison of photoacoustic and fluorescence tomography for thePhotoacoustics · 2020Article
- Feasibility Study of Precise Balloon Catheter Tracking and Visualization with Fast Photoacoustic Microscopy.Sensors (Basel, Switzerland) · 2020Article
- Photoacoustic imaging for surgical guidance: Principles, applications, and outlook.Journal of applied physics · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is well known that there are structural differences between cortical and cancellous bone. However, spinal surgeons currently have no reliable method to non-invasively determine these differences in real-time when choosing the optimal starting point and trajectory to insert pedicle screws and avoid surgical complications associated with breached or weakened bone. This paper explores 3D photoacoustic imaging of a human vertebra to noninvasively differentiate cortical from cancellous bone for this surgical task. We observed that signals from the cortical bone tend to appear as compact, high-amplitude signals, while signals from the cancellous bone have lower amplitudes and are more diffuse. In addition, we discovered that the location of the light source for photoacoustic imaging is a critical parameter that can be adjusted to non-invasively determine the optimal entry point into the pedicle. Once inside the pedicle, statistically significant differences in the contrast and SNR of signals originating from the cancellous core of the pedicle (when compared to signals originating from the surrounding cortical bone) were obtained with laser energies of 0.23-2.08 mJ (p < 0.05). Similar quantitative differences were observed with an energy of 1.57 mJ at distances ⩾6 mm from the cortical bone of the pedicle. These quantifiable differences between cortical and cancellous bone (when imaging with an ultrasound probe in direct contact with each bone type) can potentially be used to ensure an optimal trajectory during surgery. Our results are promising for the introduction and development of photoacoustic imaging systems to overcome a wide range of longstanding challenges with spinal surgeries, including challenges with the occurrence of bone breaches due to misplaced pedicle screws.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.