Evidence map›Paper›PMID 29923443›Full record

ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS

Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly.

Roberta Fernanda da Silva, Riccardo Lacchini, Lucas Cezar Pinheiro, Thiago José Dionísio, AndréMourão Jacomini, José Eduardo Tanus-Santos, Sandra Lia Amaral, Carlos Ferreira Santos, Anderson Saranz Zago

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In one paragraph

Article in Journal of the renin-angiotensin-aldosterone system : JRAAS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Roberta Fernanda da Silva1 Department of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, Brazil.ORCID https://orcid.org/0000-0002-8177-9356
Riccardo Lacchini2 School of Nursing of Ribeirão Preto, USP - University of São Paulo, Ribeirão Preto, Brazil.
Lucas Cezar Pinheiro3 Faculty of Medicine of Ribeirão Preto, USP - University of São Paulo, Ribeirão Preto, Brazil.
Thiago José Dionísio4 Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
AndréMourão Jacomini1 Department of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, Brazil.
José Eduardo Tanus-Santos3 Faculty of Medicine of Ribeirão Preto, USP - University of São Paulo, Ribeirão Preto, Brazil.
Sandra Lia Amaral1 Department of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, Brazil.
Carlos Ferreira Santos4 Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
Anderson Saranz Zago1 Department of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade de Ribeirão Preto · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePolymorphisms of the renin angiotensin system (RAS) are associated with increases in blood pressure (BP). Physical exercise has been considered the main strategy to prevent this increase. This study aimed to investigate the relationship between estimated training status (TS), BP and angiotensin-converting enzyme (ACE) activity in elderly people classified as low or high risk to develop hypertension according to genetic profile.

methodsA total of 155 elderly participants performed the following assessments: general functional fitness index (GFFI), systolic BP (SBP) and diastolic BP (DBP), blood collection for ACE activity and analyses of the RAS polymorphisms.

resultsUncontrolled hypertensive (UHT) participants presented higher values of SBP and DBP compared with normotensive (NT) and controlled hypertensive (CHT) participants. No differences were found in ACE activity and GFFI between groups. In the high risk group, UHT presented higher values of SBP and DBP compared with other groups. CHT presented higher values of SBP compared with NT. Furthermore, UHT presented higher values of ACE activity compared with CHT and lower values of GFFI compared with NT.

conclusionMDA, TIA and TIC genetic combinations were associated with high risk of developing hypertension while the maintenance of good levels of TS was associated with lower BP values and ACE activity.

Indexed as

Polymorphism, GeneticAgedAllelesBlood PressureFemaleGenotypeHemodynamicsHumansHypertensionMalePeptidyl-Dipeptidase ARenin-Angiotensin SystemACE protein, humanPeptidyl-Dipeptidase Ablood pressureelderlyphysical fitnessPolymorphismsRAS

Identifiers

PMID29923443
PMCPMC6024535
OpenAlexW2809001374

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.