Evidence map›Paper›PMID 29923425›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2018

Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.

Hany E A Ahmed, Mohammed A A El-Nassag, Ahmed H Hassan, Rawda M Okasha, Saleh Ihmaid, Ahmed M Fouda, Tarek H Afifi, Ateyatallah Aljuhani, Ahmed M El-Agrody

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. RSC medicinal chemistry · 2024
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  12. Development of Novel Class of Phenylpyrazolo[3,4-International journal of molecular sciences · 2023
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  13. Synthesis of 9-Hydroxy-1International journal of molecular sciences · 2022
    Article
  14. Article
  15. A New Family of Benzo[International journal of molecular sciences · 2021
    Article
  16. Article
  17. Article
  18. Design and Synthesis of Novel Heterocyclic-Based 4Molecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Hany E A Ahmeda Department of Pharmacy College, Pharmacognosy and Pharmaceutical Chemistry , Taibah University , Al-Madinah Al-Munawarah , Saudi Arabia.
Mohammed A A El-Nassagc Chemistry Department, Faculty of Science , Al-Azhar University , Cairo , Egypt.
Ahmed H Hassanc Chemistry Department, Faculty of Science , Al-Azhar University , Cairo , Egypt.
Rawda M Okashae Chemistry Department, Faculty of Science , Taibah University , Al-Madinah Al-Munawarah , Saudi Arabia.
Saleh Ihmaida Department of Pharmacy College, Pharmacognosy and Pharmaceutical Chemistry , Taibah University , Al-Madinah Al-Munawarah , Saudi Arabia.
Ahmed M Foudaf Chemistry Department, Faculty of Science , King Khalid University , Abha , Saudi Arabia.
Tarek H Afifie Chemistry Department, Faculty of Science , Taibah University , Al-Madinah Al-Munawarah , Saudi Arabia.
Ateyatallah Aljuhanie Chemistry Department, Faculty of Science , Taibah University , Al-Madinah Al-Munawarah , Saudi Arabia.
Ahmed M El-Agrodyc Chemistry Department, Faculty of Science , Al-Azhar University , Cairo , Egypt.
Taibah University · SAAl-Azhar University · EGJazan University · SAKing Khalid University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our effort to develop novel and powerful agents with anti-proliferative activity, two new series of 1H-benzo[f]chromene derivatives, 4a-h and 6a-h, were synthesised using heterocyclocondensation methodologies under microwave irradiation condition. The structures of the target compounds were established on the basis of their spectral data, IR,

Indexed as

Antineoplastic AgentsCell ProliferationCSK Tyrosine-Protein KinaseDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMicrowavesMolecular Docking SimulationMolecular StructureProtein Kinase Inhibitorssrc-Family KinasesStructure-Activity RelationshipTumor Cells, CulturedAntineoplastic AgentsCSK protein, humanCSK Tyrosine-Protein KinaseProtein Kinase Inhibitorssrc-Family Kinases1H-benzo[f]chromenesantitumour activityCaspase 3/7Microwave synthesisSAR study

Identifiers

PMID29923425
PMCPMC6022228
OpenAlexW2809586985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.