ArticleHuman brain mapping2018
The optimistic brain: Trait optimism mediates the influence of resting-state brain activity and connectivity on anxiety in late adolescence.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Mapping trait justice sensitivity in the Brain: Whole-brain resting-state functional connectivity as a predictor of other-oriented not self-oriented justice sensitivity.Cognitive, affective & behavioral neuroscience · 2025Article
- Negative emotions mediate the association between the topology of the complex brain network and smartphone use disorder: A resting-state EEG study.Journal of behavioral addictions · 2024Article
- Association of loneliness and grey matter volume in the dorsolateral prefrontal cortex: the mediating role of interpersonal self-support traits.Brain imaging and behavior · 2023Article
- The role of healthy emotionality in the relationship between fear of COVID-19 and mental health problems: a cross-sectional study.Cognitive processing · 2022Article
- Migraine: interactions between brain's trait and state.CNS spectrums · 2022Review
- The Role of EFL/ESL Teachers' Psychological Empowerment and Optimism on Their Job Commitment.Frontiers in psychology · 2022Review
- Emotional intelligence mediates the association between middle temporal gyrus gray matter volume and social anxiety in late adolescence.European child & adolescent psychiatry · 2021Article
- Association between the dispositional optimism and depression in young people: a systematic review and meta-analysis.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2021Review
- Artificial neural network application for identifying risk of depression in high school students: a cross-sectional study.BMC psychiatry · 2021Article
- Regional gray matter volume associated with exercise dependence: A voxel-based morphometry study.Human brain mapping · 2021Article
- Reduced network integration in default mode and executive networks is associated with social and personal optimism biases.Human brain mapping · 2021Article
- Sex-linked neurofunctional basis of psychological resilience in late adolescence: a resting-state functional magnetic resonance imaging study.European child & adolescent psychiatry · 2020Article
- Neurostructural correlates of hope: dispositional hope mediates the impact of the SMA gray matter volume on subjective well-being in late adolescence.Social cognitive and affective neuroscience · 2020Article
- Neurostructural correlates of optimism: Gray matter density in the putamen predicts dispositional optimism in late adolescence.Human brain mapping · 2020Article
- Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder.Frontiers in psychiatry · 2020Article
- Stress and the brain: Perceived stress mediates the impact of the superior frontal gyrus spontaneous activity on depressive symptoms in late adolescence.Human brain mapping · 2019Review
- Brain structures and functional connectivity associated with individual differences in trait proactive aggression.Scientific reports · 2019Article
- Abnormal Alterations of Regional Spontaneous Neuronal Activity in Inferior Frontal Orbital Gyrus and Corresponding Brain Circuit Alterations: A Resting-State fMRI Study in Somatic Depression.Frontiers in psychiatry · 2019Article
- The optimistic brain: Trait optimism mediates the influence of resting-state brain activity and connectivity on anxiety in late adolescence.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a hot research topic in the field of psychology and psychiatry, trait optimism reflects the tendency to expect positive outcomes in the future. Consistent evidence has demonstrated the role of trait optimism in reducing anxiety among different populations. However, less is known about the neural bases of trait optimism and the underlying mechanisms for how trait optimism protects against anxiety in the healthy brain. In this investigation, we examined these issues in 231 healthy adolescent students by assessing resting-state brain activity (i.e., fractional amplitude of low-frequency fluctuations, fALFF) and connectivity (i.e., resting-state functional connectivity, RSFC). Whole-brain correlation analyses revealed that higher levels of trait optimism were linked with decreased fALFF in the right orbitofrontal cortex (OFC) and increased RSFC between the right OFC and left supplementary motor cortex (SMC). Mediation analyses further showed that trait optimism mediated the influence of the right OFC activity and the OFC-SMC connectivity on anxiety. Our results remained significant even after excluding the impact of head motion, positive and negative affect and depression. Taken together, this study reveals that fALFF and RSFC are functional neural markers of trait optimism and provides a brain-personality-symptom pathway for protection against anxiety in which fALFF and RSFC affect anxiety through trait optimism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.