Evidence map›Paper›PMID 29923225›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2018

Bone Turnover Markers Are Not Associated With Hip Fracture Risk: A Case-Control Study in the Women's Health Initiative.

Carolyn J Crandall, Sowmya Vasan, Andrea LaCroix, Meryl S LeBoff, Jane A Cauley, John A Robbins, Rebecca D Jackson, Douglas C Bauer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Observational
  10. Article
  11. Osteoporosis: Investigations and Monitoring.Indian journal of orthopaedics · 2023
    Review
  12. Review
  13. Follicle-stimulating hormone is associated with low bone mass in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Article
  14. The role of bone turnover markers in screening low bone mineral density and their relationship with fracture risk in the postmenopausal period.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023
    Article
  15. Management of osteoporosis in patients with chronic kidney disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Review
  16. Article
  17. Gamma-glutamyl-transferase is associated with incident hip fractures in women and men ≥ 50 years: a large population-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  18. Article
  19. Real-world bone turnover marker use: impact on treatment decisions and fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Article
  20. The Non-invasive Diagnosis of Bone Disorders in CKD.Calcified tissue international · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 1 country.

Carolyn J CrandallDivision of General Internal Medicine and Health Services Research, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.
Sowmya VasanWomen's Health Initiative, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Andrea LaCroixFamily and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA.
Meryl S LeBoffEndocrine, Diabetes, and Hypertension Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Jane A CauleyDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
John A RobbinsDepartment of Medicine, UC Davis Medical Center, Sacramento, CA, USA.
Rebecca D JacksonDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Ohio State University, Columbus, OH, USA.
Douglas C BauerDepartments of Medicine and Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Brigham and Women's Hospital · USFred Hutch Cancer Center · USOSRAM (United States) · USThe Ohio State University · USUniversity of California, Los Angeles · USUniversity of California San Diego · USUniversity of California, San Francisco · USUniversity of Pittsburgh · US

Funding

WHI Sex Hormone &Genetic Risk Factors for Hip FractureR01AR048919 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN R · 2003 to 2005
$894k
NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIAMS NIH HHS R01 AR048919
6 · The paper itself

Abstract

Current guidelines recommend that serum C-terminal telopeptide of type I collagen (CTX) and serum procollagen type 1 aminoterminal propeptide (PINP), measured by standardized assays, be used as reference markers in observational and interventional studies. However, there are limited data to determine whether serum CTX and PINP are associated with hip fracture risk among postmenopausal women. We determined the associations of serum CTX and serum PINP with hip fracture risk among postmenopausal women aged 50 to 79 years at baseline. We performed a prospective case-control study (400 cases, 400 controls) nested in the Women's Health Initiative Observational Study, which enrolled participants at 40 US clinical centers. Cases were women with incident hip fracture not taking osteoporosis medication; hip fractures were confirmed using medical records. Untreated controls were matched by age, race/ethnicity, and date of blood sampling. Serum CTX and serum PINP were analyzed on 12-hour fasting blood samples. The main outcome measure was incident hip fracture risk (mean follow-up 7.13 years). After adjustment for body mass index, smoking, frequency of falls, history of fracture, calcium and vitamin D intake, and other relevant covariates, neither serum CTX level nor serum PINP level was statistically significantly associated with hip fracture risk (CTX p

Indexed as

Bone RemodelingWomen's HealthAgedBiomarkersCase-Control StudiesCollagen Type IFemaleHip FracturesHumansMiddle AgedPeptide FragmentsPeptidesProcollagenRisk FactorsBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptidePeptide FragmentsPeptidesProcollagenprocollagen Type I N-terminal peptideBONE TURNOVERC-TERMINAL TELOPEPTIDE OF TYPE I COLLAGENCTXFRACTUREPINPPROCOLLAGEN TYPE 1 AMINOTERMINAL PROPEPTIDE

Identifiers

PMID29923225
PMCPMC7060935
OpenAlexW2808719147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.