Evidence map›Paper›PMID 29923177›Full record

ArticleInternational journal of cancer2018

BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia.

Adam J de Smith, Kyle M Walsh, Stephen S Francis, Chenan Zhang, Helen M Hansen, Ivan Smirnov, Libby Morimoto, Todd P Whitehead, Alice Kang, Xiaorong Shao and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Characterization of Genetic Etiologic Factors for Pediatric Acute Lymphoblastic Leukemia in Large Childhood Cancer Survivorship Cohorts.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Oncogenic Enhancers in Leukemia.Blood cancer discovery · 2024
    Review
  11. Article
  12. Overview on Aneuploidy in Childhood B-Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Novel Associations BetweenFrontiers in oncology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 1 country.

Adam J de SmithDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.ORCID 0000-0003-4880-7543
Kyle M WalshDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Stephen S FrancisDepartment of Epidemiology, School of Community Health Sciences, University of Nevada Reno, Reno, NV.
Chenan ZhangDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.ORCID 0000-0003-1773-4441
Helen M HansenDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
Ivan SmirnovDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
Libby MorimotoSchool of Public Health, University of California Berkeley, Berkeley, CA.
Todd P WhiteheadSchool of Public Health, University of California Berkeley, Berkeley, CA.
Alice KangSchool of Public Health, University of California Berkeley, Berkeley, CA.
Xiaorong ShaoSchool of Public Health, University of California Berkeley, Berkeley, CA.
Lisa F BarcellosSchool of Public Health, University of California Berkeley, Berkeley, CA.
Roberta McKean-CowdinCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA.
Luoping ZhangSchool of Public Health, University of California Berkeley, Berkeley, CA.
Cecilia FuChildren's Hospital of Los Angeles, Los Angeles, CA.
Rong WangDepartment of Chronic Diseases Epidemiology, School of Public Health, Yale University, New Haven, CT.
Herbert YuUniversity of Hawaii Cancer Center, Honolulu, HI.ORCID 0000-0003-3950-4815
Josephine HohDepartment of Chronic Diseases Epidemiology, School of Public Health, Yale University, New Haven, CT.
Andrew T DewanDepartment of Chronic Diseases Epidemiology, School of Public Health, Yale University, New Haven, CT.
Catherine MetayerSchool of Public Health, University of California Berkeley, Berkeley, CA.
Xiaomei MaDepartment of Chronic Diseases Epidemiology, School of Public Health, Yale University, New Haven, CT.
Joseph L WiemelsDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA.
Berkeley Public Health Division · USYale University · USUniversity of California, San Francisco · USUniversity of Southern California · USChildren's Hospital of Los Angeles · USDuke University · USUniversity of Hawaiʻi at Mānoa · USUniversity of Nevada, Reno · US

Funding

CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1M
Genome-Wide Association Study of Childhood Leukemia by Hispanic StatusR01CA155461 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, XIAOMEI, WIEMELS, JOSEPH LEO · 2011 to 2014
$4.1M
Project 3: Prenatal Exposure, DNA Methylation & Childhood LeukemiaP01ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2009 to 2013
$3.7M
Perinatal immune development and risk of childhood acute lymphoblastic leukemiaR01CA175737 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MA, XIAOMEI, WIEMELS, JOSEPH LEO · 2014 to 2018
$3.0M
Support For Infrastructure of Childhood Leukemia Environmental ResearchR24ES028524 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Catherine Metayer · 2017 to 2026
$2.3M
Lifespan Psychosocial Profiles and Biological Pathways to Bone StrengthR01AG033067 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRANDALL, CAROLYN JANET, KARLAMANGLA, ARUN S · 2009 to 2012
$1.4M
NCCDPHP CDC HHS U58 DP003862NCI NIH HHS R01 CA155461NCI NIH HHS R01 CA175737NIA NIH HHS R01 AG033067NIEHS NIH HHS P01 ES018172NIEHS NIH HHS R01 ES009137NIEHS NIH HHS R24 ES028524NIH HHS P01 ES018172NIH HHS R01 CA155461NIH HHS R01 CA175737NIH HHS R01 ES009137
6 · The paper itself

Abstract

Genome-wide association studies of childhood acute lymphoblastic leukemia (ALL) have identified regions of association at PIP4K2A and upstream of BMI1 at chromosome 10p12.31-12.2. The contribution of both loci to ALL risk and underlying functional variants remain to be elucidated. We carried out single nucleotide polymorphism (SNP) imputation across chromosome 10p12.31-12.2 in Latino and non-Latino white ALL cases and controls from two independent California childhood leukemia studies, and additional Genetic Epidemiology Research on Aging study controls. Ethnicity-stratified association analyses were performed using logistic regression, with meta-analysis including 3,133 cases (1,949 Latino, 1,184 non-Latino white) and 12,135 controls (8,584 Latino, 3,551 non-Latino white). SNP associations were identified at both BMI1 and PIP4K2A. After adjusting for the lead PIP4K2A SNP, genome-wide significant associations remained at BMI1, and vice-versa (p

Indexed as

Polymorphism, Single NucleotideAdolescentAdultCaliforniaCell Cycle ProteinsChildChromosome MappingChromosomes, Human, Pair 10Core Binding Factor Alpha 1 SubunitEnhancer Elements, GeneticFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansK562 CellsLinkage DisequilibriumBMI1 protein, humanCell Cycle ProteinsCore Binding Factor Alpha 1 SubunitMYBL2 protein, humanPhosphotransferases (Alcohol Group Acceptor)PIP4K2A protein, humanPolycomb Repressive Complex 1RUNX2 protein, humanTrans-ActivatorsBMI1childhood acute lymphoblastic leukemiaenhancer elementfine-mappinggenome-wide association study

Identifiers

PMID29923177
PMCPMC6235695
OpenAlexW2895665314

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.