Evidence map›Paper›PMID 29922985›Full record

ArticleBehavior genetics2018

Genetic and Environmental Influences on Verbal Fluency in Middle Age: A Longitudinal Twin Study.

Daniel E Gustavson, Matthew S Panizzon, Jeremy A Elman, Carol E Franz, Asad Beck, Chandra A Reynolds, Kristen C Jacobson, Hong Xian, Rosemary Toomey, Michael J Lyons and 1 more

Abstract readTwin Study
In one paragraph

Article in Behavior genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  2. Young adult urbanicity, late midlife neighborhood disadvantage, and cognitive functioning in community-dwelling older men.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel E GustavsonDepartment of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, 9500 Gilman Dr. (MC 0738), La Jolla, CA, 92093, USA. dgustavson@ucsd.edu.ORCID 0000-0002-1470-4928
Matthew S PanizzonDepartment of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, 9500 Gilman Dr. (MC 0738), La Jolla, CA, 92093, USA.
Jeremy A ElmanDepartment of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, 9500 Gilman Dr. (MC 0738), La Jolla, CA, 92093, USA.
Carol E FranzDepartment of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, 9500 Gilman Dr. (MC 0738), La Jolla, CA, 92093, USA.
Asad BeckDepartment of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, 9500 Gilman Dr. (MC 0738), La Jolla, CA, 92093, USA.
Chandra A ReynoldsDepartment of Psychology, University of California, Riverside, Riverside, CA, USA.
Kristen C JacobsonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Hong XianDepartment of Biostatistics, St. Louis University and Clinical Epidemiology Center, Veterans Affairs St. Louis Healthcare System, St. Louis, MO, USA.
Rosemary ToomeyDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Michael J LyonsDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
William S KremenDepartment of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, 9500 Gilman Dr. (MC 0738), La Jolla, CA, 92093, USA.

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Testosterone-Androgen Receptor Genetics: Role in Cognitive and Biological AgingK08AG047903 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PANIZZON, MATTHEW S · 2014 to 2017
$452k
NIA NIH HHS K08 AG047903NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG076838
6 · The paper itself

Abstract

Mounting evidence suggests that measures of phonemic fluency and semantic fluency are differentially associated with other cognitive and health phenotypes, but few studies have examined their shared and unique variance, especially using genetically-informative designs. In this study, 1464 middle-aged twins completed six fluency subtests at up to two time-points (mean age 56 and 62 years). Confirmatory factor analyses supported a two-factor solution: a General Fluency latent factor explained variation in all six subtests and a Semantic-Specific factor accounted for additional variance in semantic subtests. Both factors were explained primarily by genetic influences at both waves (a

Indexed as

Gene-Environment InteractionVerbal BehaviorAgingCognitionHumansLongitudinal StudiesMaleMiddle AgedModels, TheoreticalPhenotypeCategory fluencyHeritabilityLongitudinal designTwin studyWord fluency

Identifiers

PMID29922985
PMCPMC6301139

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.