ReviewJournal of neurology2019
Time window and "tissue window": two approaches to assist decision-making in strokes.
Review in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Evaluating the Safety and Efficacy of Intravenous Thrombolysis in Acute Ischemic Stroke Patients Without Perfusion Deficit: A Retrospective Analysis.Brain sciences · 2025Article
- Article
- Chronic hypertension alters the relationship between collateral blood flow cortical cerebral blood flow, and brain tissue oxygenation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- MRI-guided thrombolysis for lenticulostriate artery stroke within 12 h of symptom onset.Scientific reports · 2022Observational
- Dimensions and forms of artefacts in 1.5 T and 3 T MRI caused by cochlear implants.Scientific reports · 2022Article
- Article
- Metabolome Changes in Cerebral Ischemia.Cells · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Intravenous alteplase given in an appropriate time window has been recommended in guidelines and effects are on the decline over time. In general, the clinical decision is primarily based on whether ischemic stroke patients are sent to hospitals within the time window. However, some patients sent to the hospital over time limitations are eligible to receive intervention for recanalization due to good collateral circulation. In this dilemma, "tissue window" can be more reliable, which means using the penumbra as a major criterion for patient recruitment. Hence, we herein aim to address how could "tissue window" be a complementary approach when it does not conform to the time window's indication and affirming value of the later one. Some efforts obeying the time window are discussed first. In the later sections, we give the details of the definition of "tissue window", and then compare various neuroimaging techniques to determine the penumbra and summarize favorable patterns. Finally, we will focus on how the "tissue window" extends the therapeutic time window under specific circumstances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.