ArticleEuropean radiology2019
Two-year efficacy of single-session high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Efficacy of HIFU for the treatment of benign thyroid nodules: a systematic review and meta-analysis.European radiology · 2024Pooled it
- General Principles for the Safe Performance, Training, and Adoption of Ablation Techniques for Benign Thyroid Nodules: An American Thyroid Association Statement.Thyroid : official journal of the American Thyroid Association · 2023Article
- Safety and Efficacy of Single-Session Radiofrequency Ablation Treatment for Benign Non-toxic Multinodular Goiter.World journal of surgery · 2022Article
- Conspicuousness and recurrence related factors of ultrasound-guided microwave ablation in the treatment of benign thyroid nodules.BMC surgery · 2021Article
- Long-term outcomes of radiofrequency ablation for unifocal low-risk papillary thyroid microcarcinoma: a large cohort study of 414 patients.European radiology · 2021Article
- Article
- A Nomogram to Predict Regrowth After Ultrasound-Guided Radiofrequency Ablation for Benign Thyroid Nodules.Frontiers in endocrinology · 2021Article
- Long-Term Outcomes of Thermal Ablation for Benign Thyroid Nodules: The Issue of Regrowth.International journal of endocrinology · 2021Review
- 2020 European Thyroid Association Clinical Practice Guideline for the Use of Image-Guided Ablation in Benign Thyroid Nodules.European thyroid journal · 2020Article
- The current state and future perspectives of high intensity focused ultrasound (HIFU) ablation for benign thyroid nodules.Gland surgery · 2020Review
- Thermal Ablation of Benign Thyroid Nodules and Papillary Thyroid Microcarcinoma.Frontiers in oncology · 2020Review
- Emerging clinical applications of high-intensity focused ultrasound.Diagnostic and interventional radiology (Ankara, Turkey) · 2019Review
- High-intensity focused ultrasound (HIFU) for benign thyroid nodules: 2-year follow-up results.Endocrine · 2019Article
- High-intensity focused ultrasound ablation as a treatment for benign thyroid diseases: the present and future.Ultrasonography (Seoul, Korea) · 2019Article
- Horner's Syndrome During High-Intensity Focused Ultrasound Ablation for a Benign Thyroid Nodule.AACE clinical case reportsArticle
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAssessing the efficacy of single high-intensity focused ultrasound (HIFU) ablation in benign thyroid nodules beyond 12 months.
methodsOne hundred and eight patients underwent single HIFU treatment. Extent of nodule shrinkage [by volume reduction ratio (VRR)] and obstructive symptom score [by 0-10 visual analogue scale (VAS)] were evaluated for 24 months after treatment. VRR (%) was calculated based on the formula: [baseline volume - volume at visit] / [baseline volume] × 100. Binary logistic regression was performed to evaluate factors associated with 24-month treatment success (VRR ≥ 50%).
resultsAfter treatment, the mean (± SD) VRR at 3, 6, 12 ,18 and 24 months were 51.32 ± 20.71%, 62.99 ± 22.05%, 68.66 ± 18.48%, 69.76 ± 17.88% and 70.41 ± 17.39%, respectively, while the median (IQR) VAS at baseline, 6, 12 and 24 months was gradually lowered from 4.0 (2.0), 2.0 (1.0), 2.0 (1.0) to 1.0 (2.0), respectively. Sixty-three (58.3%) nodules had a further volume reduction (i.e. > 4.5%) from 12 to 24 months, while 22 (20.4%) nodules had a volume increase of > 4.5% from 12 to 24 months. Small pre-ablation nodule volume was a significant determinant for treatment success at 24 months (OR=1.045, 95% CI=1.021-1.092, p = 0.038).
conclusionsA majority of nodules had further volume reduction beyond 12 months after single HIFU ablation, but since one-fifth of nodules had a notable volume increase beyond 12 months, a longer period of surveillance would be necessary. Small pre-ablation nodule volume was a significant factor determining 24-month treatment success. KEY POINTS: • Small but significant nodule shrinkage continues beyond 12 months after single treatment. • Obstructive symptom continues to improve beyond 12 months after single treatment • Smaller-sized nodules have a greater chance of treatment success at 24 months.
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