ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2018
Association between quality of life and clinical characteristics in patients with morphea.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Sex- and Gender-Related Differences in Pruritus in Dermatological Diseases: Insights into Inflammatory, Autoimmune, and Connective Tissue Disorders.Life (Basel, Switzerland) · 2026Review
- Comparison of health-related quality of life in atopic dermatitis, hidradenitis suppurativa, pemphigus and psoriasis.Archives of dermatological research · 2025Article
- Neurosensory symptoms and muscle cramping in morphea: A cross-sectional study and review.Skin health and disease · 2024Article
- The Serological Evidence of Positive Rheumatoid Factor in Morphea Patients and Its Relation to Disease Severity.Cureus · 2024Article
- Clinical, Histologic, and Transcriptomic Evaluation of Sequential Fat Grafting for Morphea: A Nonrandomized Controlled Trial.JAMA dermatology · 2024Article
- Validation of the DLQI questionnaire in assessing the disease burden and principal aspects related to life quality of vitiligo patients.Frontiers in psychology · 2024Article
- Autoimmune Connective Tissue Diseases-Related Pruritus: Proper Diagnosis and Possible Mechanisms.Diagnostics (Basel, Switzerland) · 2022Review
- Assessment of health state utilities in dermatology: an experimental time trade-off value set for the dermatology life quality index.Health and quality of life outcomes · 2022Article
- Measurement properties of the ICECAP-A capability well-being instrument among dermatological patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Pruritus in autoimmune connective tissue diseases.Annals of translational medicine · 2021Review
- Health-related quality of life and its influencing factors in adult patients with localized scleroderma - a cross-sectional study.Health and quality of life outcomes · 2020Article
- Associations between Disease Activity/Severity and Damage and Health-Related Quality of Life in Adult Patients with Localized Scleroderma-A Comparison of LoSCAT and Visual Analogue Scales.Journal of clinical medicine · 2020Article
- A novel patient-reported outcome for paediatric localized scleroderma: a qualitative assessment of content validity.The British journal of dermatology · 2020Article
- Overview of Juvenile localized scleroderma and its management.World journal of pediatrics : WJP · 2020Review
- Quality of Life in Patients with Morphea: A Cross-Sectional Study and a Review of the Current Literature.BioMed research international · 2020Review
- Why, how, and when to use color Doppler ultrasound for improving precision in the diagnosis, assessment of severity and activity in morphea.Journal of scleroderma and related disorders · 2019Review
- The Role of Sex and Gender in Dermatology - From Pathogenesis to Clinical Implications.Journal of cutaneous medicine and surgeryReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMorphea can lead to considerable cosmetic or functional impairment; nevertheless, health-related quality of life (HRQoL) is rarely documented in adult morphea patients.
objectiveTo investigate the impact of morphea on HRQoL and to identify determinants of impaired HRQoL.
methodsA cross-sectional study has been carried out among adult morphea patients. HRQoL was evaluated by the Dermatology Life Quality Index (DLQI). The modified Localised Scleroderma Skin Severity Index (mLoSSI) and the Localised Scleroderma Damage Index (LoSDI) were applied to evaluate disease activity and damage, respectively. Physician Global Assessment of Activity and Damage (PGA-A, PGA-D) were also completed. Determinants of HRQoL were analysed by multiple regression.
resultsA total of 101 patients (84% females) entered the study, with a mean age of 56.8 ± 14.8 years. Median mLoSSI, LoSDI, PGA-A and PGA-D scores were 8, 5, 9 and 9 points, respectively. Patients with generalised localised (51%) and plaque-type morphea (45%) had median total DLQI scores of 4 and 1, respectively. Embarrassment (53%), itchy or painful skin (46%), and clothing issues (43%) were the most commonly reported problems in the DLQI. Female gender, generalised morphea, higher disease activity (PGA-A score) and involvement of hands and/or feet were significant predictors of impaired HRQoL (p < 0.05).
conclusionThis study represents the largest sample of adult morphea patients surveyed about their HRQoL in Europe. The frequent occurrence of embarrassment warrants an increased attention to improve patients' mental health. Care must be taken in case of involvement of functionally sensitive areas, as these cases might require more intensive treatment.
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