Evidence map›Paper›PMID 29922897›Full record

ArticleDigestive diseases and sciences2018

Is There an Effect of Cannabis Consumption on Acute Pancreatitis?

C Roberto Simons-Linares, Jodie A Barkin, Yuchen Wang, Palashkumar Jaiswal, William Trick, Michael J Bartel, Jamie S Barkin

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Innovations in pain management in patients with chronic pancreatitis.iGIE : innovation, investigation and insights · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Cannabis-Induced Pancreatitis in a Young Adult Male.Journal of investigative medicine high impact case reports
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

C Roberto Simons-LinaresGastroenterology and Hepatology Department, Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. robertosimons@outlook.com.ORCID 0000-0002-5586-3722
Jodie A BarkinDivision of Gastroenterology, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Yuchen WangJohn Stroger Hospital of Cook County, Chicago, IL, USA.
Palashkumar JaiswalJohn Stroger Hospital of Cook County, Chicago, IL, USA.
William TrickJohn Stroger Hospital of Cook County, Chicago, IL, USA.
Michael J BartelSection of Gastroenterology, Fox Chase Cancer Center, Temple Health, Philadelphia, PA, USA.
Jamie S BarkinDivision of Gastroenterology, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
John H. Stroger, Jr. Hospital of Cook County · USUniversity of Miami · USCleveland Clinic · USFox Chase Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimTwenty-percentage of acute pancreatitis (AP) cases is labeled as idiopathic. Cannabis remains the most frequently used illicit drug in the world. The aim of this study was to identify the prevalence of cannabis use among all patients with a first episode of AP, particularly in those labeled as idiopathic etiology, and determine any effect on AP severity.

methodsRetrospective cohort of all consecutive patients admitted with a first episode of AP at a large tertiary referral hospital from 01/2013 through 12/2014. AP was identified by ICD9 code, or lipase ≥ 3 times the upper limit of normal and abdominal pain consistent with AP. Cannabis users (CU) were identified via history or urine toxicology.

resultsFour hundred and sixty patients were included. 54% were men, with a mean age of 48 years (range 17-89 years). Forty-eight patients (10%) were identified as CU. After adjusting for admission SIRS, age, and gender, cannabis use was not found to be an independent risk factor for persistent SIRS, AKI, ARDS, pancreatic necrosis, mortality, ICU admission, length of stay, in-hospital infections, nor recurrent AP. Of note, AKI was least common among non-CU compared to CU (OR 0.4; p = 0.02; CI 0.2-0.9) and non-CU had a higher admission BISAP score (≥ 2) compared to CU (OR 2.5; p = 0.009; CI 1.2-4.9).

conclusionThis is the largest study to date examining cannabis use in AP. Cannabis use was found across almost all etiologies of AP with a prevalence of 10% (48 cases), and in 9% (9 cases) of so-called idiopathic AP cases in this cohort, which could account as an association for approximately 2% of all AP cases. Cannabis use did not independently impact AP severity or mortality.

Indexed as

CannabisAdolescentAdultAgedAged, 80 and overChicagoFemaleHumansMaleMiddle AgedPancreatitisRetrospective StudiesYoung AdultAcute pancreatitisCannabisDiagnosisMarijuanaPrevalence

Identifiers

PMID29922897
OpenAlexW2809278153

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.