ReviewChemical Society reviews2018
Continuous flow biocatalysis.
Review in Chemical Society reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 367 citations in OpenAlex.
- Do We Still Need Chemistry for Water-Soluble Prodrugs? What Biocatalysis Already Does, and What It Does Not.Pharmaceutics · 2026Review
- Biocatalytic Arene Functionalization Using Integrated Unspecific Peroxygenase and Halohydrin Dehalogenase.Chem & bio engineering · 2026Article
- Compartmentalized Liquid Microenvironments of Pickering Emulsion Droplets for Continuous-Flow Catalysis.JACS Au · 2026Review
- Enhanced Biocatalysis in Nanofluidic Membrane Reactors With Goldilocks Nanopores for Enzymes.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Continuous and Divergent Biotransformation of β-Ketoesters Into Enantiomerically Pure β-Hydroxyacids or Their Oligomers Through a Telescoped Multienzyme Cascade.Chembiochem : a European journal of chemical biology · 2026Article
- 3D-Printed Platforms for Enzyme Immobilisation Screening and Direct Translation into Continuous-Flow Biocatalysis.ChemSusChem · 2026Article
- How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution.Chemical Society reviews · 2026Review
- Two-Step Synthesis of a Chiral Fluorinated Alcohol With Silica-Supported Enzyme RrADH in Batch and Continuous Flow Mode.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Bioprinting of Nanocellulose Hydrogels for Photobiocatalysis Under Continuous Flow.ACS sustainable chemistry & engineering · 2026Article
- Integrating biocatalysis with continuous flow: current status, challenges, and future perspectives.Journal of advanced research · 2026Review
- An enzymatic microfluidic sensor for β-lactam antibiotics based on cross-linked ancestral β-lactamase crystals.Nanoscale advances · 2026Article
- Enzymatic aminolysis in continuous flow: an efficient strategy for the synthesis of salicylamide derivatives.RSC advances · 2026Article
- Review
- The Impact of Continuous Flow Technology and Collaboration between Academia and Industry.JACS Au · 2026Review
- Advances in solid handling for continuous flow synthesis of specialty chemicals and pharmaceuticals.Communications chemistry · 2026Review
- Current Progress and Future Directions of Enzyme Technology in Food Nutrition: A Comprehensive Review of Processing, Nutrition, and Functional Innovation.Foods (Basel, Switzerland) · 2026Review
- A modular, reusable biocatalytic flow system for UDP-GlcNAc production.Reaction chemistry & engineering · 2025Article
- Oxidative Neutralisation of Sulfur-Based Chemical Warfare Agents Mediated by a Lipase: From Batch to Flow Reactor.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Light-Driven Photobiocatalytic Oxyfunctionalization in a Continuous Reactor System without External Oxygen Supply.ACS sustainable chemistry & engineering · 2025Article
- Nanomaterial scaffolds for enzymatic polymer degradation: a tool to advance current biodegradation assessments of polymers in liquid formulation.Bioscience nanotechnology · 2025Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The continuous flow synthesis of active pharmaceutical ingredients, value-added chemicals, and materials has grown tremendously over the past ten years. This revolution in chemical manufacturing has resulted from innovations in both new methodology and technology. This field, however, has been predominantly focused on synthetic organic chemistry, and the use of biocatalysts in continuous flow systems is only now becoming popular. Although immobilized enzymes and whole cells in batch systems are common, their continuous flow counterparts have grown rapidly over the past two years. With continuous flow systems offering improved mixing, mass transfer, thermal control, pressurized processing, decreased variation, automation, process analytical technology, and in-line purification, the combination of biocatalysis and flow chemistry opens powerful new process windows. This Review explores continuous flow biocatalysts with emphasis on new technology, enzymes, whole cells, co-factor recycling, and immobilization methods for the synthesis of pharmaceuticals, value-added chemicals, and materials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.