Evidence map›Paper›PMID 29922557›Full record

ArticlePlastic and reconstructive surgery. Global open2018

Treatment of Dimpling from Cellulite.

Roberto Amore, Domenico Amuso, Vincenza Leonardi, Andrea Sbarbati, Giamaica Conti, Maria Albini, Francesco Leva, Ferdinando Terranova, Antonio Guida, Konstantinos Gkritzalas and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05885035 (Effects of Calcium Hydroxylapatite on Cellulite Dimples in the Buttocks), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05885035 phase1completednot on this mapstarted 2023, after this paper: background citation

Effects of Calcium Hydroxylapatite on Cellulite Dimples in the Buttocks

TypeinterventionalSponsorKalpna Kay Durairaj, MD, FACSRan2023 to 2023Enrolled25ConditionsCelluliteArmsCalcium Hydroxyapatite
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Article
  6. A Study of a Novel Controlled Focal Septa Release Method for Improving Cellulite.Plastic and reconstructive surgery. Global open · 2022
    Article
  7. Review
  8. Article
  9. Insights Into the Pathophysiology of Cellulite: A Review.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roberto AmoreUniversity of Palermo, Master of Techniques of Aesthetic Medicine and Wellness, Palermo, Italy.
Domenico AmusoUniversity of Palermo, Master of Techniques of Aesthetic Medicine and Wellness, Palermo, Italy.
Vincenza LeonardiUniversity of Palermo, Master of Techniques of Aesthetic Medicine and Wellness, Palermo, Italy.
Andrea SbarbatiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Giamaica ContiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Maria AlbiniICAMP - Marconi University, Segrate - Milano, Italy.
Francesco LevaICAMP - Marconi University, Segrate - Milano, Italy.
Ferdinando TerranovaSIMEO - University of Camerino, Master of Aesthetic Medicine, Roma, Italy.
Antonio GuidaSIMEO - University of Camerino, Master of Aesthetic Medicine, Roma, Italy.
Konstantinos GkritzalasAl Najat Clinical Center, Salmiya, Kuwait.
Liya GavashelyAcademy of International Interships Liya Gavashely, Moscow, Russia.
Roman VelichenkoAcademy of International Interships Liya Gavashely, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCellulite can be seen on the skin in widespread alterations of the skin surface and dimpling. The purpose of this study was to assess the effectiveness and safety of the manual subcision technique to treat dimpling from cellulite, using a specific class IIA medical device (Celluerase).

methodsThe multi-center observational study assessed 200 women treated in a single session for different dimpling, using manual subcision administered by Celluerase. Aesthetic outcomes were evaluated by the authors, and the patients assessed satisfaction levels.

resultsTwo hundred women between 20 and 55 years were treated. The medical evaluation of patients saw improvements with an average score of 8.1, whereas the subjective evaluation by patients gave an average improvement score of 7.8. Adverse events were reported. DISCUSSION: Women have septa orientation at right angels to the skin surface, and those with cellulite have an irregular septa conformation, with some septa being hypertrophic-thickened, and others being narrowed-lysed. Magnetic resonance imaging has confirmed that cellulite depressions are associated with a significant increase of thickness of underlying subcutaneous fibrous septa. Subcision has immediate results because it eliminates traction on the skin.

conclusionThe study has shown the effectiveness and safety of the manual subcision in the treatment of dimpling. The device used, designed specifically for this technique, has shown itself to be very helpful and effective in terms of practical use, aesthetic outcome and safety, with various advantages compared with other commonly used devices.

Identifiers

PMID29922557
PMCPMC5999441

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.