Evidence map›Paper›PMID 29922459›Full record

ArticleAnnals of medicine and surgery (2012)2018

Association between Q192R polymorphism in the PON1 gene and statin responses in cardiac patients.

Eman R Abd Elgwad, Eman G Behiry, Fathy M Swailem, Seham G Ameen, Dalia M Abdelhasib, Rabab O Abd Elhamid

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine and surgery (2012), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Eman R Abd ElgwadClinical& Chemical Pathology Department Faculty of Medicine, Benha University, Egypt.
Eman G BehiryClinical& Chemical Pathology Department Faculty of Medicine, Benha University, Egypt.
Fathy M SwailemCardiology Department, Faculty of Medicine, Benha University, Egypt.
Seham G AmeenClinical& Chemical Pathology Department Faculty of Medicine, Benha University, Egypt.
Dalia M AbdelhasibClinical& Chemical Pathology Department Faculty of Medicine, Benha University, Egypt.
Rabab O Abd ElhamidClinical& Chemical Pathology Department Faculty of Medicine, Benha University, Egypt.
Benha University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionParaoxonases are a group of different forms enzymes that consist of three non-similar isoforms,

methodsThe studied population included three hundred patients with coronary artery disease with dyslipidemia who were prescribed statins. Total lipid profile was measured in these patients both before and after approximately 6 months of treatment. Q192R polymorphism of

resultsThere were no significant differences in baseline lipid levels according to different genotypes in all studied casesof Q192R (rs662) polymorphism. HDL-C goals were attained less often in patients with RR homozygosity than in Q allele carriers. Analysis by univariate logistic regression confirmed that QQ/QR carriers had an increased chance of attaining HDL-C goals.

conclusionThis study shows that the Q192R polymorphism of

Indexed as

DyslipidemiaPON1Q192R polymorphismStatin

Identifiers

PMID29922459
PMCPMC6004736
OpenAlexW2799604326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.