ArticleBone & joint research2018
Tissue engineering strategies for the treatment of tendon injuries: a systematic review and meta-analysis of animal models.
Article in Bone & joint research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Efficacy of electro-acupuncture in postpartum with diastasis recti abdominis: A randomized controlled clinical trial.Frontiers in public health · 2022Trial
- An overview in tendon's physiology, pathomorphology, and treatment options.Cell and tissue research · 2026Review
- Advances in Achilles Tendon Tissue Engineering: Integrating Cells, Scaffolds, and Mechanical Loading for Functional Regeneration.Bioengineering (Basel, Switzerland) · 2025Review
- Regenerative medicine: Hydrogels and mesoporous silica nanoparticles.Materials today. Bio · 2024Article
- Current clinical opinion on surgical approaches and rehabilitation of hand flexor tendon injury-a questionnaire study.Frontiers in medical technology · 2024Article
- Anisotropic wood-hydrogel composites: Extending mechanical properties of wood towards soft materials' applications.Materials today. Bio · 2023Article
- Bioactive Nanostructured Scaffold-Based Approach for Tendon and Ligament Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2023Review
- Tendon 3D Scaffolds Establish a Tailored Microenvironment Instructing Paracrine Mediated Regenerative Amniotic Epithelial Stem Cells Potential.Biomedicines · 2022Article
- Autologous bone marrow-derived mesenchymal stem cells provide complete regeneration in a rabbit model of the Achilles tendon bundle rupture.International orthopaedics · 2021Article
- Basic Quality Controls Used in Skin Tissue Engineering.Life (Basel, Switzerland) · 2021Review
- Nanocomposite Films of Chitosan-Grafted Carbon Nano-Onions for Biomedical Applications.Molecules (Basel, Switzerland) · 2020Article
- Effects of rabbit pinna-derived blastema cells on tendon healing.Iranian journal of basic medical sciences · 2020Article
- Preparation of Chitosan/Poly(Vinyl Alcohol) Nanocomposite Films Incorporated with Oxidized Carbon Nano-Onions (Multi-Layer Fullerenes) for Tissue-Engineering Applications.Biomolecules · 2019Article
- The ins and outs of engineering functional tissues and organs: evaluating the in-vitro and in-situ processes.Current opinion in organ transplantation · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRecently, the field of tissue engineering has made numerous advances towards achieving artificial tendon substitutes with excellent mechanical and histological properties, and has had some promising experimental results. The purpose of this systematic review is to assess the efficacy of tissue engineering in the treatment of tendon injuries.
methodsWe searched MEDLINE, Embase, and the Cochrane Library for the time period 1999 to 2016 for trials investigating tissue engineering used to improve tendon healing in animal models. The studies were screened for inclusion based on randomization, controls, and reported measurable outcomes. The RevMan software package was used for the meta-analysis.
resultsA total of 388 references were retrieved and 35 studies were included in this systematic review. The different biomaterials developed were analyzed and we found that they improve the biomechanical and histological characteristics of the repaired tendon. At meta-analysis, despite a high heterogeneity, it revealed a statistically significant effect in favour of the maximum load, the maximum stress, and the Young's modulus between experimental and control groups. In the forest plot, the diamond was on the right side of the vertical line and did not intersect with the line, favouring experimental groups.
conclusionsThis review of the literature demonstrates the heterogeneity in the tendon tissue engineering literature. Several biomaterials have been developed and have been shown to enhance tendon healing and regeneration with improved outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.