ArticleBone & joint research2018
High-fat/high-sucrose diet-induced obesity results in joint-specific development of osteoarthritis-like degeneration in a rat model.
Article in Bone & joint research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 56 citations in OpenAlex.
- Gut-Joint Axis: The Role of Exercise on Gut Microbiota and Acetic Acid Modulation in Obesity-Associated Osteoarthritis Rats.Metabolites · 2026Article
- Osteoarthritis as a systemic disease.Nature reviews. Rheumatology · 2026Review
- Salubrious effects ofFood & nutrition research · 2026Article
- Investigating inflammation of adipose tissue in a diet induced obesity model of OA in female sprague dawley rats.Scientific reports · 2025Article
- Cardioprotective Effect ofInternational journal of molecular sciences · 2025Article
- A novelOsteoarthritis and cartilage open · 2024Article
- Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat-High-Sucrose Diet in a Rat Model.Cartilage · 2024Article
- Development of shoulder osteoarthritis and bone lesions in female and male rats subjected to a high fat/sucrose diet.Scientific reports · 2024Article
- Gene therapy forProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The application of human medical image-based finite element analysis in the construction of mouse osteoarthritis models.Heliyon · 2024Article
- Regulation of Neuropeptide Y Receptor Gene Expression and Hormone Level in Obese Male Rats Receiving 6-Gingerol and L-Arginine Supplementation.Archives of Razi Institute · 2024Article
- Protective effects of silymarin-loaded chitosan nanoparticles in the diet-induced hyperlipidemia rat model.Iranian journal of basic medical sciences · 2024Article
- The impact of metabolic syndrome on clinical outcomes following total knee arthroplasty in osteoarthritis patients.Annals of joint · 2024Article
- High-fat diet aggravates the severity of the in vitro posttraumatic osteoarthritis model through macrophagic FBW7.Immunity, inflammation and disease · 2023Article
- The role of PIEZO ion channels in the musculoskeletal system.American journal of physiology. Cell physiology · 2023Review
- Effects of different obesogenic diets on joint integrity, inflammation and intermediate monocyte levels in a rat groove model of osteoarthritis.Frontiers in physiology · 2023Article
- Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies.International journal of molecular sciences · 2022Review
- Probiotic Therapy withMicroorganisms · 2022Article
- Effect of short-term high fat diet on resistin levels and expression of autophagy-related genes in the cartilage of male rats.Scientific reports · 2022Article
- The repair effect and mechanism of continuous passive motion on osteoarthritis in a rabbit model.American journal of translational research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMetabolic syndrome and low-grade systemic inflammation are associated with knee osteoarthritis (OA), but the relationships between these factors and OA in other synovial joints are unclear. The aim of this study was to determine if a high-fat/high-sucrose (HFS) diet results in OA-like joint damage in the shoulders, knees, and hips of rats after induction of obesity, and to identify potential joint-specific risks for OA-like changes.
methodsA total of 16 male Sprague-Dawley rats were allocated to either the diet-induced obesity group (DIO, 40% fat, 45% sucrose, n = 9) or a chow control diet (n = 7) for 12 weeks. At sacrifice, histological assessments of the shoulder, hip, and knee joints were performed. Serum inflammatory mediators and body composition were also evaluated. The total Mankin score for each animal was assessed by adding together the individual Modified Mankin scores across all three joints. Linear regression modelling was conducted to evaluate predictive relationships between serum mediators and total joint damage.
resultsThe HFS diet, in the absence of trauma, resulted in increased joint damage in the shoulder and knee joints of rats. Hip joint damage, however, was not significantly affected by DIO, consistent with findings in human studies. The total Mankin score was increased in DIO animals compared with the chow group, and was associated with percentage of body fat. Positive significant predictive relationships for total Mankin score were found between body fat and two serum mediators (interleukin 1 alpha (IL-1α) and vascular endothelial growth factor (VEGF)).
conclusionSystemic inflammatory alterations from DIO in this model system may result in a higher risk for development of knee, shoulder, and multi-joint damage with a HFS diet.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.