Evidence map›Paper›PMID 29922331›Full record

ReviewFrontiers in genetics2018

Sex Differences in Neurotoxicogenetics.

Carolina Torres-Rojas, Byron C Jones

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Carolina Torres-RojasDepartment of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, United States.
Byron C JonesDepartment of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, United States.
University of Tennessee Health Science Center · US

Funding

Neural Toxicity of Paraquat is Related to Iron Regulation in the MidbrainR01ES022614 · NIEHS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JONES, BYRON C, LU, LU · 2014 to 2018
$2.8M
NIEHS NIH HHS R01 ES022614
6 · The paper itself

Abstract

A major development in biomedical research is the recognition that the sex of an individual plays a key role in susceptibility, treatment, and outcomes of most diseases. In this contribution, we present evidence that sex is also important in the toxicity of many environmental toxicants and contributes to the effect of genetics. Thus, individual differences in response to toxicants includes genetic makeup, the environment and sex; in fact, sex differences may be considered a part of genetic constitution. In this review, we present evidence for sex contribution to susceptibility for a number of toxicants.

Indexed as

drugsimprinting effectsneurotoxicitysex differencessex susceptibilitytoxicantstoxicogenetics

Identifiers

PMID29922331
PMCPMC5996082
OpenAlexW2803356376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.