Evidence map›Paper›PMID 29922298›Full record

ArticleFrontiers in immunology2018

T Cell Receptor-Major Histocompatibility Complex Interaction Strength Defines Trafficking and CD103

Anna Sanecka, Nagisa Yoshida, Elizabeth Motunrayo Kolawole, Harshil Patel, Brian D Evavold, Eva-Maria Frickel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Protective function and differentiation cues of brain-resident CD8+ T cells during surveillance of latentProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer.Advances in experimental medicine and biology · 2024
    Article
  5. What's the Catch? The Significance of Catch Bonds in T Cell Activation.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  6. Keeping T cell memories in mind.Trends in immunology · 2022
    Review
  7. Human T lymphocytes at tumor sites.Seminars in immunopathology · 2022
    Review
  8. Review
  9. Formation of Tissue-Resident CD8Cold Spring Harbor perspectives in biology · 2021
    Review
  10. Relationship of 2D Affinity to T Cell Functional Outcomes.International journal of molecular sciences · 2020
    Review
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Anna SaneckaHost-Toxoplasma Interaction Laboratory, The Francis Crick Institute, London, United Kingdom.
Nagisa YoshidaHost-Toxoplasma Interaction Laboratory, The Francis Crick Institute, London, United Kingdom.
Elizabeth Motunrayo KolawoleDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, United States.
Harshil PatelBioinformatics and Biostatistics, The Francis Crick Institute, London, United Kingdom.
Brian D EvavoldBioinformatics and Biostatistics, The Francis Crick Institute, London, United Kingdom.
Eva-Maria FrickelHost-Toxoplasma Interaction Laboratory, The Francis Crick Institute, London, United Kingdom.
The Francis Crick Institute · GBUniversity of Utah · US

Funding

Evolution of CD8+ TCR affinity during chronic viral infectionR01AI096879 · NIAID · EMORY UNIVERSITY · PI EVAVOLD, BRIAN D · 2012 to 2016
$2.1M
Cancer Research UK FC001076Medical Research Council FC001076Medical Research Council MC_UP_1202/12NIAID NIH HHS HHSN272201300006CNIAID NIH HHS R01 AI096879Wellcome Trust 091664/B/10/ZWellcome Trust FC001076
6 · The paper itself

Abstract

T cell receptor-major histocompatibility complex (TCR-MHC) affinities span a wide range in a polyclonal T cell response, yet it is undefined how affinity shapes long-term properties of CD8 T cells during chronic infection with persistent antigen. Here, we investigate how the affinity of the TCR-MHC interaction shapes the phenotype of memory CD8 T cells in the chronically

Indexed as

Immunologic MemoryAdoptive TransferAnimalsAntigens, CDAntigens, ProtozoanBiomarkersBrainCalciumCD8-Positive T-LymphocytesFlow CytometryHigh-Throughput Nucleotide SequencingImmunophenotypingIntegrin alpha ChainsLymphocyte ActivationMajor Histocompatibility ComplexMicealpha E integrinsAntigens, CDAntigens, ProtozoanBiomarkersCalciumIntegrin alpha ChainsProtozoan ProteinsReceptors, Antigen, T-CellCD8 T cellsneurological infection and inflammationROP7T cell receptor–major histocompatibility complex interactionToxoplasma gondii

Identifiers

PMID29922298
PMCPMC5996069
OpenAlexW2805722263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.