Evidence map›Paper›PMID 29922295›Full record

ReviewFrontiers in immunology2018

Genetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity.

Nicolas Gaudenzio, Thomas Marichal, Stephen J Galli, Laurent L Reber

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Inactivation of cofilin-1 in Mcpt5-Cre-nf-Cfl1Frontiers in immunology · 2025
    Article
  4. Article
  5. Review
  6. Special Issue "Molecular Studies of Dermatitis: From Mechanism to Therapy".International journal of molecular sciences · 2024
    Article
  7. Article
  8. Article
  9. Role of Innate Immunity in Allergic Contact Dermatitis: An Update.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Roles of Mast Cells in Cutaneous Diseases.Frontiers in immunology · 2022
    Review
  17. Review
  18. Article
  19. Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Nicolas GaudenzioUnité de Différenciation Epithéliale et Autoimmunité Rhumatoïde (UDEAR), UMR 1056, INSERM, Université de Toulouse, Toulouse, France.
Thomas MarichalLaboratory of Cellular and Molecular Immunology, GIGA Institute, Liege University, Liège, Belgium.
Stephen J GalliDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, United States.
Laurent L ReberUnit of Antibodies in Therapy and Pathology, INSERM Unit 1222, Department of Immunology, Institut Pasteur, Paris, France.
Inserm · FRInstitut Pasteur · FRStanford University · USUniversity of Liège · BE

Funding

Tracking allergen specific T cells in multi-food allergyU19AI104209 · NIAID · STANFORD UNIVERSITY · PI CHINTHRAJAH, R. SHARON · 2013 to 2025
$17.3M
Role of nociceptive sensory neuron/mast cell interactions in cutaneous allergic inflammationR01AI132494 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2017 to 2021
$2.4M
RabGEF1 in MyD88 signaling, skin immunity, and atopic dermatitisR01AR067145 · NIAMS · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2015 to 2019
$1.9M
NIAID NIH HHS R01 AI132494NIAID NIH HHS U19 AI104209NIAMS NIH HHS R01 AR067145
6 · The paper itself

Abstract

Contact hypersensitivity (CHS) is a common T cell-mediated skin disease induced by epicutaneous sensitization to haptens. Mast cells (MCs) are widely deployed in the skin and can be activated during CHS responses to secrete diverse products, including some with pro-inflammatory and anti-inflammatory functions. Conflicting results have been obtained regarding pathogenic versus protective roles of MCs in CHS, and this has been attributed in part to the limitations of certain models for studying MC functions

Indexed as

Genetic Predisposition to DiseaseMolecular ImagingAnimalsBiomarkersCell DegranulationCytokinesDermatitis, ContactDisease Models, AnimalHumansInflammation MediatorsMast CellsMicroscopy, FluorescenceSecretory VesiclesBiomarkersCytokinesInflammation Mediatorsavidincontact hypersensitivityIgEinterleukin-10mast cellsmouse modelstumor necrosis factor-alphatwo photon microscopy

Identifiers

PMID29922295
PMCPMC5996070
OpenAlexW2803906736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.