Evidence map›Paper›PMID 29922291›Full record

ArticleFrontiers in immunology2018

Transcriptomics of the Vaccine Immune Response: Priming With Adjuvant Modulates Recall Innate Responses After Boosting.

Francesco Santoro, Elena Pettini, Dmitri Kazmin, Annalisa Ciabattini, Fabio Fiorino, Gregor D Gilfillan, Ida M Evenroed, Peter Andersen, Gianni Pozzi, Donata Medaglini

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

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  14. Immune Memory After Respiratory Infection WithFrontiers in cellular and infection microbiology · 2022
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  19. Review
  20. Computational Analysis of Multiparametric Flow Cytometric Data to Dissect B Cell Subsets in Vaccine Studies.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Francesco SantoroLaboratorio di Microbiologia Molecolare e Biotecnologia (LA.M.M.B.), Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy.
Elena PettiniLaboratorio di Microbiologia Molecolare e Biotecnologia (LA.M.M.B.), Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy.
Dmitri KazminEmory Vaccine Center, Emory University, Atlanta, GA, United States.
Annalisa CiabattiniLaboratorio di Microbiologia Molecolare e Biotecnologia (LA.M.M.B.), Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy.
Fabio FiorinoLaboratorio di Microbiologia Molecolare e Biotecnologia (LA.M.M.B.), Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy.
Gregor D GilfillanDepartment of Medical Genetics, Oslo University Hospital, University of Oslo, Oslo, Norway.
Ida M EvenroedDepartment of Medical Genetics, Oslo University Hospital, University of Oslo, Oslo, Norway.
Peter AndersenDepartment of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.
Gianni PozziLaboratorio di Microbiologia Molecolare e Biotecnologia (LA.M.M.B.), Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy.
Donata MedagliniLaboratorio di Microbiologia Molecolare e Biotecnologia (LA.M.M.B.), Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy.
University of Siena · ITEmory University · USOslo University Hospital · NOStatens Serum Institut · DKUniversity of Oslo · NO

Funding

NIAID NIH HHS HHSN272201300006C
6 · The paper itself

Abstract

Transcriptomic profiling of the immune response induced by vaccine adjuvants is of critical importance for the rational design of vaccination strategies. In this study, transcriptomics was employed to profile the effect of the vaccine adjuvant used for priming on the immune response following re-exposure to the vaccine antigen alone. Mice were primed with the chimeric vaccine antigen H56 of

Indexed as

Gene Expression ProfilingImmunologic MemoryTranscriptomeAdjuvants, ImmunologicAnimalsComputational BiologyFemaleGene Expression RegulationHigh-Throughput Nucleotide SequencingImmunityImmunity, CellularImmunity, HumoralImmunity, InnateImmunizationImmunization, SecondaryLymphocyte SubsetsAdjuvants, ImmunologicTuberculosis VaccinesVaccinesadaptive immunityCAF01recall innate responseRNA sequencingvaccine adjuvant

Identifiers

PMID29922291
PMCPMC5996052
OpenAlexW2806228149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.