Evidence map›Paper›PMID 29922272›Full record

ArticleFrontiers in microbiology2018

Gut Microbiota Markers in Obese Adolescent and Adult Patients: Age-Dependent Differential Patterns.

Federica Del Chierico, Francesca Abbatini, Alessandra Russo, Andrea Quagliariello, Sofia Reddel, Danila Capoccia, Romina Caccamo, Stefano Ginanni Corradini, Valerio Nobili, Francesco De Peppo and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03990350 (Comparison of the Gut Microbiota Composition in Caucasian Hispanic and Caucasian Non-Hispanic Children With and Without Obesity), which is not on this map. Cited by 112 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03990350 completednot on this mapstarted 2019, after this paper: background citation

Comparison of the Gut Microbiota Composition in Caucasian Hispanic and Caucasian Non-Hispanic Children With and Without Obesity

TypeobservationalSponsorNemours Children's ClinicRan2019 to 2020Enrolled17ConditionsObesityArmsFecal Sample Collection, Physical Activity Questionnaire, Food Frequency Questionnaire, 24-hour dietary recall diary
3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 2 syntheses or guidelines pooled it, 179 citations in OpenAlex.

  1. Pooled it
  2. Diet, adiposity, and the gut microbiota from infancy to adolescence: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
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  19. Gut Microbial Changes Associated With Obesity in Youth With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2025
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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Federica Del ChiericoHuman Microbiome Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Francesca AbbatiniDepartment of Medical Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Bariatric Center of Excellence IFSO-EU, Sapienza University, Rome, Italy.
Alessandra RussoHuman Microbiome Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Andrea QuagliarielloHuman Microbiome Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Sofia ReddelHuman Microbiome Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Danila CapocciaDepartment of Experimental Medicine, Section of Endocrinology, Sapienza University, Rome, Italy.
Romina CaccamoPediatric General Surgery Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Stefano Ginanni CorradiniGastroenterology Unit, Department of Clinical Medicine, Sapienza University, Rome, Italy.
Valerio NobiliDepartment of Pediatrics, Sapienza University, Rome, Italy.
Francesco De PeppoPediatric General Surgery Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Bruno DallapiccolaScientific Directorate, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Frida LeonettiDepartment of Experimental Medicine, Section of Endocrinology, Sapienza University, Rome, Italy.
Gianfranco SilecchiaDepartment of Medical Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Bariatric Center of Excellence IFSO-EU, Sapienza University, Rome, Italy.
Lorenza PutignaniHuman Microbiome Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Bambino Gesù Children's Hospital · ITSapienza University of Rome · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity levels, especially in children, have dramatically increased over the last few decades. Recently, several studies highlighted the involvement of gut microbiota in the pathophysiology of obesity. We investigated the composition of gut microbiota in obese adolescents and adults compared to age-matched normal weight (NW) volunteers in order to assemble age- and obesity-related microbiota profiles. The composition of gut microbiota was analyzed by 16S rRNA-based metagenomics. Ecological representations of microbial communities were computed, and univariate, multivariate, and correlation analyses performed on bacterial profiles. The prediction of metagenome functional content from 16S rRNA gene surveys was carried out. Ecological analyses revealed a dissimilarity among the subgroups, and resultant microbiota profiles differed between obese adolescents and adults. Using statistical analyses, we assigned, as microbial markers,

Indexed as

bacterial markersdysbiosisgut microbiotametabolic pathwaysobesity

Identifiers

PMID29922272
PMCPMC5996250
OpenAlexW2803790829

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.