ArticleFrontiers in neuroscience2018
Lateral Symmetry of Synergies in Lower Limb Muscles of Acute Post-stroke Patients After Robotic Intervention.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Control strategies used in lower limb exoskeletons for gait rehabilitation after brain injury: a systematic review and analysis of clinical effectiveness.Journal of neuroengineering and rehabilitation · 2023Pooled it
- Systematic review on wearable lower-limb exoskeletons for gait training in neuromuscular impairments.Journal of neuroengineering and rehabilitation · 2021Pooled it
- Changes in leg cycling muscle synergies after training augmented by functional electrical stimulation in subacute stroke survivors: a pilot study.Journal of neuroengineering and rehabilitation · 2020Trial
- Task complexity amplifies spatial asymmetry of muscle synergy plasticity in chronic stroke survivors.Journal of neuroengineering and rehabilitation · 2026Article
- Axial MRI evaluation of temporomandibular joint condylar and lateral pterygoid muscle angles in anterior disc displacement.Scientific reports · 2025Article
- Noninvasive spatiotemporal spinal neuromodulation targeting dorsal roots improves paretic leg motor control during walking in persons with stroke.Journal of neurophysiology · 2025Article
- Comparative analysis of muscle synergies in gait of stroke patients and healthy controls.Frontiers in human neuroscience · 2025Article
- Article
- Muscle Synergy Analysis as a Tool for Assessing the Effectiveness of Gait Rehabilitation Therapies: A Methodological Review and Perspective.Bioengineering (Basel, Switzerland) · 2024Review
- Neuromuscular Mechanisms of Motor Adaptation to Repeated Treadmill-Slip Perturbations During Stance in Healthy Young Adults.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024Article
- Robotic exoskeleton embodiment in post-stroke hemiparetic patients: an experimental study about the integration of the assistance provided by the REFLEX knee exoskeleton.Scientific reports · 2023Article
- Lower extremity robotic exoskeleton devices for overground ambulation recovery in acquired brain injury-A review.Frontiers in neurorobotics · 2023Review
- Age-related differences in gait symmetry obtained from kinematic synergies and muscle synergies of lower limbs during childhood.Biomedical engineering online · 2022Article
- Association Between Temporal Asymmetry and Muscle Synergy During Walking With Rhythmic Auditory Cueing in Survivors of Stroke Living With Impairments.Archives of rehabilitation research and clinical translation · 2022Article
- Neurorehabilitation using a voluntary driven exoskeletal robot improves trunk function in patients with chronic spinal cord injury: a single-arm study.Neural regeneration research · 2022Article
- Coordination Between Partial Robotic Exoskeletons and Human Gait: A Comprehensive Review on Control Strategies.Frontiers in bioengineering and biotechnology · 2022Review
- Merged swing-muscle synergies and their relation to walking characteristics in subacute post-stroke patients: An observational study.PloS one · 2022Observational
- Article
- Effect of hybrid assistive limb treatment on maximal walking speed and six-minute walking distance during stroke rehabilitation: a pilot study.Journal of physical therapy science · 2021Article
- Analysis of Gait Motion Changes by Intervention Using Robot Suit Hybrid Assistive Limb (HAL) in Myelopathy Patients After Decompression Surgery for Ossification of Posterior Longitudinal Ligament.Frontiers in neurorobotics · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gait disturbance is commonly associated with stroke, which is a serious neurological disease. With current technology, various exoskeletons have been developed to provide therapy, leading to many studies evaluating the use of such exoskeletons as an intervention tool. Although these studies report improvements in patients who had undergone robotic intervention, they are usually reported with clinical assessment, which are unable to characterize how muscle activations change in patients after robotic intervention. We believe that muscle activations can provide an objective view on gait performance of patients. To quantify improvement of lateral symmetry before and after robotic intervention, muscle synergy analysis with Non-Negative Matrix Factorization was used to evaluate patients' EMG data. Eight stroke patients in their acute phase were evaluated before and after a course of robotic intervention with the Hybrid Assistive Limb (HAL), lasting over 3 weeks. We found a significant increase in similarity between lateral synergies of patients after robotic intervention. This is associated with significant improvements in gait measures like walking speed, step cadence, stance duration percentage of gait cycle. Clinical assessments [Functional Independence Measure-Locomotion (FIM-Locomotion), FIM-Motor (General), and Fugl-Meyer Assessment-Lower Extremity (FMA-LE)] showed significant improvements as well. Our study shows that muscle synergy analysis can be a good tool to quantify the change in neuromuscular coordination of lateral symmetry during walking in stroke patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.