ArticleFrontiers in neuroscience2018
Specific Patterns of White Matter Alterations Help Distinguishing Alzheimer's and Vascular Dementia.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 70 citations in OpenAlex.
- Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers: Post Hoc Secondary Analysis of the SPRINT MIND Randomized Clinical Trial.JAMA network open · 2023Trial
- The enigma of vascular dementia: current state and emerging perspectives.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Hypertension as a Major Risk Factor in Alzheimer's Disease: Mechanisms, Interactions and Therapeutic Perspectives.Clinical interventions in aging · 2026Review
- Updates on vascular dementia.Stroke and vascular neurology · 2025Review
- Cerebellar control over inter-regional excitatory/inhibitory dynamics discriminates execution from observation of an action.Cerebellum (London, England) · 2025Article
- Deep learning reveals pathology-confirmed neuroimaging signatures in Alzheimer's, vascular and Lewy body dementias.Brain : a journal of neurology · 2025Article
- Cognitive Impairment in Cerebral Small Vessel Disease Is Associated with Corpus Callosum Microstructure Changes Based on Diffusion MRI.Diagnostics (Basel, Switzerland) · 2024Article
- Aging, Neurodegenerative Disorders, and Cerebellum.International journal of molecular sciences · 2024Review
- Gray and White Matter Voxel-Based Morphometry of Alzheimer's Disease With and Without Significant Cerebrovascular Pathologies.Neuroscience insights · 2024Article
- New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment.Frontiers in cellular neuroscience · 2024Review
- Unraveling the link: white matter damage, gray matter atrophy and memory impairment in patients with subcortical ischemic vascular disease.Frontiers in neuroscience · 2024Article
- Collaborative Learning through a Virtual Community of Practice in Dementia Care Support: A Scoping Review.Healthcare (Basel, Switzerland) · 2023Article
- Value of white matter hyperintensity volume and total white matter volume for evaluating cognitive impairment in patients with cerebral small-vessel disease.Frontiers in aging neuroscience · 2023Article
- Alzheimer's and vascular disease classification using regional texture biomarkers in FLAIR MRI.NeuroImage. Clinical · 2023Article
- Role of Citicoline in Patients With Mild Cognitive Impairment.Neuroscience insights · 2023Review
- Sleep, physical activity, sedentary behavior, and risk of incident dementia: a prospective cohort study of 431,924 UK Biobank participants.Molecular psychiatry · 2022Article
- White matter hyperintensity topography in Alzheimer's disease and links to cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- The role of inflammasomes in vascular cognitive impairment.Molecular neurodegeneration · 2022Review
- Relationships between cerebral small vessel diseases markers and cognitive performance in stroke-free patients with atrial fibrillation.Frontiers in aging neuroscience · 2022Article
- Morphological classification and changes in dementia (Review).Experimental and therapeutic medicine · 2022Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer disease (AD) and vascular dementia (VaD) together represent the majority of dementia cases. Since their neuropsychological profiles often overlap and white matter lesions are observed in elderly subjects including AD, differentiating between VaD and AD can be difficult. Characterization of these different forms of dementia would benefit by identification of quantitative imaging biomarkers specifically sensitive to AD or VaD. Parameters of microstructural abnormalities derived from diffusion tensor imaging (DTI) have been reported to be helpful in differentiating between dementias, but only few studies have used them to compare AD and VaD with a voxelwise approach. Therefore, in this study a whole brain statistical analysis was performed on DTI data of 93 subjects (31 AD, 27 VaD, and 35 healthy controls-HC) to identify specific white matter patterns of alteration in patients affected by VaD and AD with respect to HC. Parahippocampal tracts were found to be mainly affected in AD, while VaD showed more spread white matter damages associated with thalamic radiations involvement. The genu of the corpus callosum was predominantly affected in VaD, while the splenium was predominantly affected in AD revealing the existence of specific patterns of alteration useful in distinguishing between VaD and AD. Therefore, DTI parameters of these regions could be informative to understand the pathogenesis and support the etiological diagnosis of dementia. Further studies on larger cohorts of subjects, characterized for brain amyloidosis, will allow to confirm and to integrate the present findings and, furthermore, to elucidate the mechanisms of mixed dementia. These steps will be essential to translate these advances to clinical practice.
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