ArticleNature communications2018
Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 119 citations in OpenAlex.
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- ATG7 in innate immune cells is required for host defense against nontuberculous mycobacterial pulmonary infections.Nature communications · 2025Article
- Multifunctional Magnetic Ionic Liquid-Carbon Nanohorn Complexes for Targeted Cancer Theranostics.Small science · 2025Article
- Recent Advances in Wearable Thermal Devices for Virtual and Augmented Reality.Micromachines · 2025Review
- Carbon Nanomaterials in Biomedicine: Opportunities and Toxicological Concerns.International journal of nanomedicine · 2025Review
- Applications of pyroptosis activators in tumor immunotherapy.Materials today. Bio · 2024Review
- Biomimetic Functional Nanocomplexes for Photothermal Cancer Chemoimmunotheranostics.Small science · 2024Article
- Black phosphorus for bone regeneration: Mechanisms involved and influencing factors.Materials today. Bio · 2024Review
- Nanomedicine-induced programmed cell death enhances tumor immunotherapy.Journal of advanced research · 2024Review
- Carbon Nanomaterial Fluorescent Probes and Their Biological Applications.Chemical reviews · 2024Review
- Graphene-Based Photodynamic Therapy and Overcoming Cancer Resistance Mechanisms: A Comprehensive Review.International journal of nanomedicine · 2024Review
- Nanomaterials as protein mimics or nanologicals.Nanomedicine (London, England) · 2024Article
- Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation.Nature communications · 2023Article
- Preclinical evaluation of modified carbon nanohorns and their complexation with insulin.Nanoscale advances · 2023Article
- Nanomaterial-induced pyroptosis: a cell type-specific perspective.Frontiers in cell and developmental biology · 2023Review
- Nanomedicine-Enabled/Augmented Cell Pyroptosis for Efficient Tumor Nanotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Understanding the immunological interactions of engineered nanomaterials: Role of the bio-corona.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- Development of a Novel MR Colonography via Iron-Based Solid Lipid Nanoparticles.International journal of nanomedicine · 2022Article
- One-pot preparation of nanodispersion with readily available components for localized tumor photothermal and photodynamic therapy.Asian journal of pharmaceutical sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Single-walled carbon-nanohorns (SNH) exhibit huge application prospects. Notably, spherical SNH possess different morphology from conventional carbon nanotubes (CNT). However, there is a tremendous lack of studies on the nanotoxicity and mechanism of SNH, and their comparison with nanotubes. Here, the dissimilarity between SNH and CNT is found in many aspects including necrosis, pyroptosis, apoptosis, protein expression, hydrolases leakage, lysosome stress, membrane disturbance and the interaction with membrane proteins. The improved biocompatibility of SNH over four types of established CNT is clearly demonstrated in macrophages. Importantly, a key transmembrane protein, glycoprotein nonmetastatic melanoma protein B (GPNMB) is discovered to initiate the nanotoxicity. Compared to CNT, the weaker nano-GPNMB interaction in SNH group induces lower degree of cascade actions from nano/membrane interplay to final cell hypotoxicity. In conclusion, the geometry of single-construct unit, but not that of dispersive forms or intracellular levels of nanocarbons make the most difference.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.