Evidence map›Paper›PMID 29921848›Full record

ArticleScientific reports2018

Inhibition of the substantia nigra pars reticulata produces divergent effects on sensorimotor gating in rats and monkeys.

Brittany L Aguilar, Patrick A Forcelli, Ludise Malkova

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  10. Pharmacological Inactivation of the Bed Nucleus of the Stria Terminalis Increases Affiliative Social Behavior in Rhesus Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  11. Article
  12. Article
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  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brittany L AguilarInterdisciplinary Program in Neuroscience, Georgetown University, Washington DC, 20057, USA.
Patrick A ForcelliInterdisciplinary Program in Neuroscience, Georgetown University, Washington DC, 20057, USA. paf22@georgetown.edu.ORCID 0000-0003-1763-060X
Ludise MalkovaInterdisciplinary Program in Neuroscience, Georgetown University, Washington DC, 20057, USA. malkoval@georgetown.edu.

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Institutional Career Development CoreKL2TR001432 · NCATS · GEORGETOWN UNIVERSITY · PI UMANS, JASON G · 2015 to 2024
$7.5M
Predoctoral Training in Intergrative NeuroscienceT32NS041231 · NINDS · GEORGETOWN UNIVERSITY · PI Ludise Malkova, Ashley S VanMeter · 2001 to 2026
$6.8M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2016 to 2020
$5.9M
Optogenetic control of seizures via the basal gangliaR01NS097762 · NINDS · GEORGETOWN UNIVERSITY · PI Patrick Alexander Forcelli · 2016 to 2026
$4.1M
Training in Neural Injury &PlasticityT32NS041218 · NINDS · GEORGETOWN UNIVERSITY · PI MARK P BURNS, Kathleen Anne Maguire-Zeiss · 2001 to 2026
$3.5M
Limbic-Basal Ganglia Circuitry in PTSDR01MH099505 · NIMH · GEORGETOWN UNIVERSITY · PI MALKOVA, LUDISE · 2013 to 2017
$2.3M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS UL1 TR001409NICHD NIH HHS U54 HD090257NIMH NIH HHS R01 MH099505NINDS NIH HHS L40 NS103805NINDS NIH HHS R01 NS097762NINDS NIH HHS T32 NS041218NINDS NIH HHS T32 NS041231
6 · The paper itself

Abstract

The basal ganglia are an evolutionarily old group of structures, with gross organization conserved across species. Despite this conservation, there is evidence suggesting that anatomical organization of a key output nucleus of the basal ganglia, the substantia nigra pars reticulata (SNpr), diverges across species. Nevertheless, there are relatively few comparative studies examining the impact of manipulations of SNpr across species. Here, we evaluated the role of SNpr in a highly conserved behavior: prepulse inhibition of the acoustic startle response (PPI). We performed parallel experiments in both rats and rhesus macaques using intracranial microinfusions of GABA

Indexed as

AnimalsGABA-A Receptor AgonistsMacacaMaleMuscimolPars ReticulataRatsSensory GatingSubstantia NigraGABA-A Receptor AgonistsMuscimol

Identifiers

PMID29921848
PMCPMC6008324

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.