ArticleScientific reports2018
Tannin-rich extracts from Lannea stuhlmannii and Lannea humilis (Anacardiaceae) exhibit hepatoprotective activities in vivo via enhancement of the anti-apoptotic protein Bcl-2.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 62 citations in OpenAlex.
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- Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism.BMC complementary medicine and therapies · 2023Article
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- RETRACTED: A Polyphenol-Rich Fraction fromPharmaceuticals (Basel, Switzerland) · 2020Article
- Chemical Composition, Antioxidant, Anti-Tyrosinase, Anti-Cholinesterase and Cytotoxic Activities of Essential Oils of Six Algerian Plants.Molecules (Basel, Switzerland) · 2020Article
- Grape-Leaf Extract Attenuates Alcohol-Induced Liver Injury via Interference with NF-κB Signaling Pathway.Biomolecules · 2020Article
- In vitro Antioxidant and in vivo Hepatoprotective Activities of Root Bark Extract and Solvent Fractions ofJournal of experimental pharmacology · 2020Article
- A Polyphenol-Rich Extract FromFrontiers in veterinary science · 2020Article
- Chemical Profiling of Polyphenolics inAntioxidants (Basel, Switzerland) · 2019Article
- Chrysophanol, Physcion, Hesperidin and Curcumin Modulate the Gene Expression of Pro-Inflammatory Mediators Induced by LPS in HepG2: In Silico and Molecular Studies.Antioxidants (Basel, Switzerland) · 2019Article
- Identification, Quantification, and Antioxidant Activity of Hydroalcoholic Extract ofTurkish journal of pharmaceutical sciences · 2019Article
- Review of Ethnomedicinal, Phytochemical and Pharmacological Properties ofMolecules (Basel, Switzerland) · 2019Review
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potential hepatoprotective activities of two Lannea species were explored in vivo. Furthermore, the binding activities of their main polyphenols to the antiapoptotic protein Bcl-2 were investigated. Based on HPLC-MS/MS results, 22 secondary metabolites were characterized in L. stuhlmannii (mainly tannins), while 20 secondary metabolites (mainly sulphated tannins) were identified in L. humilis. Both extracts exhibited substantial antioxidant activities in vitro and counteracted D-galactosamine induced intoxication in rats in vivo and increased the total antioxidant capacity (TAC) of liver tissues. In addition to reducing the elevated levels of AST and total bilirubin, both extracts significantly attenuated the deleterious histopathologic changes in liver after D-galactosamine-intoxication. Also, both extracts protected hepatocytes from apoptotic cell death and increased the expression of the anti-apoptotic protein Bcl-2. The identified compounds from both extracts can bind to the Bcl-2: Bim (BH3) interface with an appreciable binding free energy. Hydrogen and ionic bonds and hydrophobic interactions with amino acid residues in the hydrophobic face of Bim (BH3) domain were discovered. To sum up, L. humilis and L. stuhlmanni exhibited promising hepatoprotective activities in vivo against D-GalN-induced liver injury and their hepatoprotection is due to the antioxidant and anti-apoptotic effects of tannins and proanthocyanidins.
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