Evidence map›Paper›PMID 29921717›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Dysregulation of NAD

Yo Sasaki, Amber R Hackett, Sungsu Kim, Amy Strickland, Jeffrey Milbrandt

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Pmp2+ Schwann Cells Maintain the Survival of Large-Caliber Motor Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Macrophage depletion blocks congenital SARM1-dependent neuropathy.The Journal of clinical investigation · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Age-related NADExperimental gerontology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yo SasakiDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110 sasaki@wustl.edu.
Amber R HackettDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110.
Sungsu KimDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110.ORCID 0000-0002-8644-2517
Amy StricklandDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110.
Jeffrey MilbrandtDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110.
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
PHYSIOLOGY AND GENETICS OF THE GDNF HOMOLOG NEURTURINR01AG013730 · NIA · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 1996 to 2026
$10.6M
DISSECTION OF SARM1-INDUCED AXON DEGENERATION AND CELL DEATHR01NS087632 · NINDS · WASHINGTON UNIVERSITY · PI Aaron Diantonio, JEFFREY D MILBRANDT · 2014 to 2026
$6.4M
TRAINING PROGRAM IN ANESTHESIOLOGY RESEARCHT32GM108539 · NIGMS · WASHINGTON UNIVERSITY · PI Aaron J Norris · 2014 to 2026
$4.9M
NERVOUS SYSTEM DEVELOPMENT AND INJURYT32NS007205 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 1985 to 2017
$4.2M
Regulating NAD Metabolism to Inhibit Axon Degeneration in Neurodegenerative DiseasesRF1AG013730 · NIA · WASHINGTON UNIVERSITY · PI MILBRANDT, JEFFREY D · 2017 to 2017
$2.8M
Metabolic Regulation of the Schwann Cell Injury ResponseR56NS099314 · NINDS · WASHINGTON UNIVERSITY · PI MILBRANDT, JEFFREY D · 2017 to 2017
$477k
NCI NIH HHS P30 CA091842NIA NIH HHS R01 AG013730NIA NIH HHS RF1 AG013730NIGMS NIH HHS T32 GM108539NINDS NIH HHS R01 NS087632NINDS NIH HHS R56 NS099314NINDS NIH HHS T32 NS007205
6 · The paper itself

Abstract

The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the importance of SC metabolism in nerve function and in peripheral neuropathies associated with metabolic disorders. Nicotinamide adenine dinucleotide (NAD

Indexed as

AnimalsCell DedifferentiationFemaleMaleMiceMice, Inbred C57BLMice, KnockoutNADPeripheral Nervous System DiseasesSchwann CellsNADmetabolismmyelinNAD+NAMPTperipheral neuropathySchwann cell

Identifiers

PMID29921717
PMCPMC6052240
OpenAlexW2809507114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.