ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Anterior Thalamic Excitation and Feedforward Inhibition of Presubicular Neurons Projecting to Medial Entorhinal Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Article
- Medial entorhinal VIP-expressing interneurons receive input from the thalamic anterior dorsal nucleus and are critical for spatial memory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Altered Hippocampal Subfields Functional Connectivity in Benign Paroxysmal Positional Vertigo Patients With Residual Dizziness: A Resting-State fMRI Study.CNS neuroscience & therapeutics · 2024Article
- Local origin of excitatory-inhibitory tuning equivalence in a cortical network.Nature neuroscience · 2024Article
- Spatially structured inhibition defined by polarized parvalbumin interneuron axons promotes head direction tuning.Science advances · 2021Article
- Time to put the mammillothalamic pathway into context.Neuroscience and biobehavioral reviews · 2021Review
- Molecular Characterization of Superficial Layers of the Presubiculum During Development.Frontiers in neuroanatomy · 2021Article
- The head direction cell network: attractor dynamics, integration within the navigation system, and three-dimensional properties.Current opinion in neurobiology · 2020Review
- The effects of developmental alcohol exposure on the neurobiology of spatial processing.Neuroscience and biobehavioral reviews · 2019Review
- Burst Firing and Spatial Coding in Subicular Principal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Multiple Patterns of Axonal Collateralization of Single Layer III Neurons of the Rat Presubiculum.Frontiers in neural circuits · 2019Article
- From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior.Frontiers in molecular neuroscience · 2019Article
- Inhibitory Connectivity Dominates the Fan Cell Network in Layer II of Lateral Entorhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
The presubiculum contains head direction cells that are crucial for spatial orientation. Here, we examined the connectivity and strengths of thalamic inputs to presubicular layer 3 neurons projecting to the medial entorhinal cortex in the mouse. We recorded pairs of projection neurons and interneurons while optogenetically stimulating afferent fibers from the anterior thalamic nuclei. Thalamic input differentially affects presubicular neurons: layer 3 pyramidal neurons and fast-spiking parvalbumin-expressing interneurons are directly and monosynaptically activated, with depressing dynamics, whereas somatostatin-expressing interneurons are indirectly excited, during repetitive anterior thalamic nuclei activity. This arrangement ensures that the thalamic excitation of layer 3 cells is often followed by disynaptic inhibition. Feedforward inhibition is largely mediated by parvalbumin interneurons, which have a high probability of connection to presubicular pyramidal cells, and it may enforce temporally precise head direction tuning during head turns. Our data point to the potential contribution of presubicular microcircuits for fine-tuning thalamic head direction signals transmitted to medial entorhinal cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.