Evidence map›Paper›PMID 29921671›Full record

ArticlemBio2018

The PGRS Domain of Mycobacterium tuberculosis PE_PGRS Protein Rv0297 Is Involved in Endoplasmic Reticulum Stress-Mediated Apoptosis through Toll-Like Receptor 4.

Sonam Grover, Tarina Sharma, Yadvir Singh, Sakshi Kohli, Manjunath P, Aditi Singh, Torsten Semmler, Lothar H Wieler, Karsten Tedin, Nasreen Z Ehtesham and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 98 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Cell death pathways in response toInfection and immunity · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. The PE/PPE family proteins ofFrontiers in immunology · 2025
    Review
  9. Article
  10. Article
  11. Journal of clinical tuberculosis and other mycobacterial diseases · 2024
    Review
  12. Article
  13. Article
  14. Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Review
  15. Biology · 2024
    Article
  16. Review
  17. Review
  18. Frontiers in tuberculosis · 2024
    Article
  19. Virulence · 2023
    Article
  20. Virulence Factors ofPathogens (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Sonam Grover *JH Institute of Molecular Medicine, Jamia Hamdard, New Delhi, India.
Tarina Sharma *Molecular Infection and Functional Biology Lab, Kusuma School of Biological Sciences, Indian Institute of Technology-Delhi, New Delhi, India.
Yadvir Singh *Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.
Sakshi KohliCentre for Infectious Disease and Research, Indian Institute of Science, Bangalore, India.
Manjunath PNational Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.
Aditi SinghSchool of Biotechnology, Jawaharlal Nehru University, New Delhi, India.
Torsten SemmlerMicrobial Genomics Research Group, Robert Koch Institute, Berlin, Germany.ORCID 0000-0002-2225-7267
Lothar H WielerMicrobial Genomics Research Group, Robert Koch Institute, Berlin, Germany.
Karsten TedinCentre for Infection Medicine, Institute of Microbiology and Epizootics, Berlin, Germany.
Nasreen Z EhteshamNational Institute of Pathology, Safdarjung Hospital Campus, New Delhi, India.
Seyed E HasnainJH Institute of Molecular Medicine, Jamia Hamdard, New Delhi, India seyedhasnain@gmail.com.
Jamia Hamdard · INRobert Koch Institute · DESafdarjang Hospital · INIndian Institute of Science Bangalore · INIndian Institute of Technology Delhi · INJawaharlal Nehru University · INMax Planck Institute for Infection Biology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genome of

Indexed as

ApoptosisEndoplasmic Reticulum StressAnimalsAntigens, BacterialBacterial ProteinsEndoplasmic ReticulumEndoplasmic Reticulum Chaperone BiPHEK293 CellsHost-Pathogen InteractionsHumansMacrophagesMembrane ProteinsMiceMycobacterium tuberculosisProtein BindingProtein Sorting SignalsAntigens, BacterialBacterial ProteinsEndoplasmic Reticulum Chaperone BiPHSPA5 protein, humanHspa5 protein, mouseMembrane ProteinsPE-PGRS protein, MycobacteriumProtein Sorting SignalsToll-Like Receptor 4calcium homeostasisER localization signalgranulomasunfolded protein response

Identifiers

PMID29921671
PMCPMC6016250
OpenAlexW2808915963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.