ArticlemBio2018
CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection.
Open access · goldAbstract read
In one paragraph
Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 56 citations in OpenAlex.
- Substrate secretion by different EHEC secretion systems during their interaction with epithelial cells.Virulence · 2026Article
- Mapping in-cell protein contact sites reveals hijacking of paraspeckles during influenza A virus infection.Nature microbiology · 2026Article
- Dissecting conserved molecular mechanisms of biological toxin activity through CRISPR screening.Biochemical Society transactions · 2026Review
- Article
- LAPTM5 Confers the Resistance to Venetoclax via Promoting the Autophagosome-Lysosome Fusion in Multiple Myeloma.Journal of cellular and molecular medicine · 2025Article
- Enhancing food safety in soybean fermentation through strategic implementation of starter cultures.Heliyon · 2024Review
- Gaining New Insights into Fundamental Biological Pathways by Bacterial Toxin-Based Genetic Screens.Bioengineering (Basel, Switzerland) · 2023Review
- FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins.Life science alliance · 2023Article
- Targeting the Inside of Cells with Biologicals: Toxin Routes in a Therapeutic Context.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023Review
- Recent Advances in CRISPR-Cas Technologies for Synthetic Biology.Journal of microbiology (Seoul, Korea) · 2023Review
- Genome-wide CRISPR screens and their applications in infectious disease.Frontiers in genome editing · 2023Review
- Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking.Cell reports · 2022Article
- Identification of two lipid phosphatases that regulate sphingosine-1-phosphate cellular uptake and recycling.Journal of lipid research · 2022Article
- Pathogenomes and variations in Shiga toxin production among geographically distinct clones ofMicrobial genomics · 2022Article
- Genome-Wide CRISPR-Cas9 Screen Does Not Identify Host Factors Modulating Streptococcus agalactiae β-Hemolysin/Cytolysin-Induced Cell Death.Microbiology spectrum · 2022Article
- Role of Globotriaosylceramide in Physiology and Pathology.Frontiers in molecular biosciences · 2022Review
- The application of genome-wide CRISPR-Cas9 screens to dissect the molecular mechanisms of toxins.Computational and structural biotechnology journal · 2022Review
- Two Paralogous Gb3/CD77 Synthases in Birds Show Different Preferences for Their Glycoprotein and Glycosphingolipid Substrates.International journal of molecular sciences · 2021Article
- Hemolytic uremic syndrome associated with Shiga toxin-producing Escherichia coli infection in Argentina: update of serotypes and genotypes and their relationship with severity of the disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Cross-species RNA-seq for deciphering host-microbe interactions.Nature reviews. Genetics · 2021Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Alline R PachecoDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Jacob E LazarusDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Brandon SitDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Stefanie SchmiederDivision of Gastroenterology, Boston Children's Hospital, Boston, Massachusetts, USA.
Wayne I LencerDivision of Gastroenterology, Boston Children's Hospital, Boston, Massachusetts, USA.
Carlos J BlondelDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
John G DoenchBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Brigid M DavisDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Matthew K WaldorDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA mwaldor@research.bwh.harvard.edu.
Harvard University · USBoston Children's Hospital · USBrigham and Women's Hospital · USBroad Institute · US
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4MINFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1MVibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3MIntestinal Disease-enterocyte toxin interactionR37DK048106 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LENCER, WAYNE I · 2011 to 2020
$7.0MHoward Hughes Medical InstituteNIAID NIH HHS R01 AI042347NIAID NIH HHS T32 AI007061NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R37 DK048106
Abstract
Enterohemorrhagic
Indexed as
Biosynthetic PathwaysCell LineCell SurvivalClustered Regularly Interspaced Short Palindromic RepeatsEnterohemorrhagic Escherichia coliEpithelial CellsEscherichia coli InfectionsGene TargetingGenetic LociGenome-Wide Association StudyHost-Pathogen InteractionsHumansMutationShiga ToxinSphingolipidsTrihexosylceramidesglobotriaosylceramideShiga ToxinSphingolipidsTrihexosylceramidesType III Secretion SystemsVirulence FactorsCRISPR screenEHECEPEChost susceptibilityLAPTM4AShiga toxinsphingolipid synthesisT3SSTM9SF2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.