Evidence map›Paper›PMID 29921652›Full record

ArticleCirculation research2018

Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of miR-125b.

Changchen Xiao, Kan Wang, Yinchuan Xu, Hengxun Hu, Na Zhang, Yingchao Wang, Zhiwei Zhong, Jing Zhao, Qingju Li, Dan Zhu and 9 more

Abstract read
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In one paragraph

Article in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 5 pooled it
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 5 syntheses or guidelines pooled it, 306 citations in OpenAlex.

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  19. METTL3-dependent mAutophagy · 2025
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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Changchen XiaoFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Kan WangFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Yinchuan XuFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Hengxun HuFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Na ZhangFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Yingchao WangFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Zhiwei ZhongFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Jing ZhaoFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Qingju LiFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Dan ZhuFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Changle KeFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Shuhan ZhongFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Xianpeng WuFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Hong YuFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Wei ZhuFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Jinghai ChenFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Jianyi ZhangDepartment of Biomedical Engineering, University of Alabama at Birmingham (J.Z.).
Jian'an WangFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Xinyang HuFrom the Department of Cardiology, Second Affiliated Hospital, College of Medicine (C.X., K.W., Y.X., H.H., N.Z., Y.W., Z.Z., J.Z., Q.L., D.Z., C.K., S.Z., X.W., H.Y., W.Z., J.C., J.W., X.H.).
Zhejiang University · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleAutophagy can preserve cell viability under conditions of mild ischemic stress by degrading damaged organelles for ATP production, but under conditions of severe ischemia, it can promote cell death and worsen cardiac performance. Mesenchymal stem cells (MSCs) are cardioprotective when tested in animal models of myocardial infarction, but whether these benefits occur through the regulation of autophagy is unknown.

objectiveTo determine whether transplanted MSCs reduce the rate of autophagic degradation (autophagic flux) in infarcted hearts and if so, to characterize the mechanisms involved. METHODS AND

resultsTreatment with transplanted MSCs improved cardiac function and infarct size while reducing apoptosis and measures of autophagic flux (bafilomycin A1-induced LC3-II [microtubule-associated protein 1 light chain 3] accumulation and autophagosome/autolysosome prevalence) in infarcted mouse hearts. In hypoxia and serum deprivation-cultured neonatal mouse cardiomyocytes, autophagic flux and cell death, as well as p53-Bnip3 (B-cell lymphoma 2-interacting protein 3) signaling, declined when the cells were cultured with MSCs or MSC-secreted exosomes (MSC-exo), but the changes associated with MSC-exo were largely abolished by pretreatment with the exosomal inhibitor GW4869. Furthermore, a mimic of the exosomal oligonucleotide miR-125b reduced, whereas an anti-miR-125b oligonucleotide increased, autophagic flux and cell death, via modulating p53-Bnip3 signaling in hypoxia and serum deprivation-cultured neonatal mouse cardiomyocytes. In the in vivo mouse myocardial infarction model, MSC-exo, but not the exosomes obtained from MSCs pretreated with the anti-miR-125b oligonucleotide (MSC-exo

conclusionsThe beneficial effects offered by MSC transplantation after myocardial infarction are at least partially because of improved autophagic flux through excreted exosome containing mainly miR-125b-5p.

Indexed as

AutophagyAnimalsCells, CulturedExosomesMaleMesenchymal Stem Cell TransplantationMiceMice, Inbred C57BLMicroRNAsMyocardial InfarctionRNAi TherapeuticsMicroRNAsMirn125 microRNA, mouseautophagymesenchymal stromal cellsmicroRNAsmyocardial infarctionstem cells

Identifiers

PMID29921652
OpenAlexW2808912161

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.