Evidence map›Paper›PMID 29921613›Full record

Trial reportBMJ (Clinical research ed.)2018

Comparison of prostatic artery embolisation (PAE) versus transurethral resection of the prostate (TURP) for benign prostatic hyperplasia: randomised, open label, non-inferiority trial.

Dominik Abt, Lukas Hechelhammer, Gautier Müllhaupt, Stefan Markart, Sabine Güsewell, Thomas M Kessler, Hans-Peter Schmid, Daniel S Engeler, Livio Mordasini

2 registry-linked trialsOpen access · hybridAbstract readComparative StudyEquivalence TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 119 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 15 pooled it
39.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02054013 nacompletednot on this map

Prostatic Artery Embolization vs. Conventional Transurethral Prostatectomy in the Treatment of Benign Prostatic Hyperplasia: A Prospective Randomized Trial

TypeinterventionalSponsorDaniel Stephan EngelerRan2014 to 2022Enrolled101ConditionsBenign Prostatic HyperplasiaArmsProstatic artery embolization, monopolar transurethral prostatectomy
NCT05531240 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Transurethral Prostate Resection (TURP) vs. Prostate Artery Embolization (PAE): Open Multicentric Randomized Study for Evaluation of Outcomes, Complications, and Health Economics

TypeinterventionalSponsorUppsala UniversityRan2022 to 2025Enrolled104ConditionsTransurethral Resection of Prostate Syndrome, Prostate Hyperplasia, Embolization, TherapeuticArmsProstate Artery Embolization, Transurethral Prostate Resection (TURP)
3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 15 syntheses or guidelines pooled it, 291 citations in OpenAlex.

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  15. Novel minimally invasive treatments for lower urinary tract symptoms: a systematic review and network meta-analysis.International braz j urol : official journal of the Brazilian Society of Urology
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59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dominik AbtDepartment of Urology, St Gallen Cantonal Hospital, 9007 St Gallen, Switzerland dominik.abt@kssg.ch.
Lukas HechelhammerDepartment of Radiology and Nuclear Medicine, St Gallen Cantonal Hospital, St Gallen, Switzerland.
Gautier MüllhauptDepartment of Urology, St Gallen Cantonal Hospital, 9007 St Gallen, Switzerland.
Stefan MarkartDepartment of Radiology and Nuclear Medicine, St Gallen Cantonal Hospital, St Gallen, Switzerland.
Sabine GüsewellClinical Trials Unit, St Gallen Cantonal Hospital, St Gallen, Switzerland.
Thomas M KesslerNeuro-Urology, Spinal Cord Injury Center and Research, University of Zürich, Balgrist University Hospital, Zürich, Switzerland.
Hans-Peter SchmidDepartment of Urology, St Gallen Cantonal Hospital, 9007 St Gallen, Switzerland.
Daniel S EngelerDepartment of Urology, St Gallen Cantonal Hospital, 9007 St Gallen, Switzerland.
Livio MordasiniDepartment of Urology, St Gallen Cantonal Hospital, 9007 St Gallen, Switzerland.
Kantonsspital St. Gallen · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare prostatic artery embolisation (PAE) with transurethral resection of the prostate (TURP) in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia in terms of patient reported and functional outcomes.

designRandomised, open label, non-inferiority trial.

settingUrology and radiology departments of a Swiss tertiary care centre.

participants103 patients aged ≥40 years with refractory lower urinary tract symptoms secondary to benign prostatic hyperplasia were randomised between 11 February 2014 and 24 May 2017; 48 and 51 patients reached the primary endpoint 12 weeks after PAE and TURP, respectively.

interventionsPAE performed with 250-400 μm microspheres under local anaesthesia versus monopolar TURP performed under spinal or general anaesthesia. MAIN OUTCOMES AND MEASURES: Primary outcome was change in international prostate symptoms score (IPSS) from baseline to 12 weeks after surgery; a difference of less than 3 points between treatments was defined as non-inferiority for PAE and tested with a one sided

resultsMean reduction in IPSS from baseline to 12 weeks was -9.23 points after PAE and -10.77 points after TURP. Although the difference was less than 3 points (1.54 points in favour of TURP (95% confidence interval -1.45 to 4.52)), non-inferiority of PAE could not be shown (P=0.17). None of the patient reported secondary outcomes differed significantly between treatments when tested for superiority; IPSS also did not differ significantly (P=0.31). At 12 weeks, PAE was less effective than TURP regarding changes in maximum rate of urinary flow (5.19

conclusionsThe improvement in lower urinary tract symptoms secondary to benign prostatic hyperplasia seen 12 weeks after PAE is close to that after TURP. PAE is associated with fewer complications than TURP but has disadvantages regarding functional outcomes, which should be considered when selecting patients. Further comparative study findings, including longer follow-up, should be evaluated before PAE can be considered as a routine treatment.

trial registrationClinicaltrials.gov NCT02054013.

Indexed as

AgedEmbolization, TherapeuticHumansMaleProstateProstatic HyperplasiaTreatment Outcome

Identifiers

PMID29921613
PMCPMC6006990
OpenAlexW2809631697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.