ArticleBiological psychiatry2018
Impaired Midline Theta Power and Connectivity During Proactive Cognitive Control in Schizophrenia.
Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Neurophysiological and autonomic effects of Cognitive Remediation Therapy in schizophrenia: a randomized controlled EEG-GSR study.BMC psychiatry · 2026Trial
- Attenuated theta-band activity and cross-frequency coupling in schizophrenia during affective response inhibition.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Response Monitoring Theta-Band Activities Across Emotional Contexts in Schizophrenia and Bipolar Spectrum Disorders.Biological psychiatry global open science · 2025Article
- Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025Article
- Oscillatory signatures of monitoring and anticipatory strategies for probabilistic vs deterministic cues.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Cognitive control impairment in ax-continuous performance test in patients with schizophrenia: A pilot EEG study.Brain and behavior · 2023Article
- Neurophysiological Measures of Proactive and Reactive Control in Negative Template Use.Journal of cognitive neuroscience · 2023Article
- Closed-loop enhancement and neural decoding of cognitive control in humans.Nature biomedical engineering · 2023Article
- The Effects of the Inhalant Toluene on Cognitive Function and Behavioral Flexibility: A Review of Recent Findings.Addiction neuroscience · 2023Article
- Neural mass model-based study of frontal-temporal theta oscillations in human subjects during the performance of a cognitive control task.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2022Article
- Dissociable theta networks underlie the switch and mixing costs during task switching.Human brain mapping · 2021Article
- Frontal midline theta differentiates separate cognitive control strategies while still generalizing the need for cognitive control.Scientific reports · 2021Article
- Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients.NPJ schizophrenia · 2021Article
- Disorganization of Oscillatory Activity in Animal Models of Schizophrenia.Frontiers in neural circuits · 2021Review
- Joint analysis of frontal theta synchrony and white matter following mild traumatic brain injury.Brain imaging and behavior · 2020Article
- Differing functional mechanisms underlie cognitive control deficits in psychotic spectrum disorders.Journal of psychiatry & neuroscience : JPN · 2020Article
- Association of Magnetoencephalographically Measured High-Frequency Oscillations in Visual Cortex With Circuit Dysfunctions in Local and Large-scale Networks During Emerging Psychosis.JAMA psychiatry · 2020Article
- Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia.Brain : a journal of neurology · 2020Article
- Lateral Prefrontal Theta Oscillations Reflect Proactive Cognitive Control Impairment in Males With Attention Deficit Hyperactivity Disorder.Frontiers in systems neuroscience · 2020Article
Corrections and comments
- Commented on by
Authors and funding
14 authors.
Funding
Abstract
backgroundDisrupted proactive cognitive control, a form of early selection and active goal maintenance, is hypothesized to underlie the broad cognitive deficits observed in patients with schizophrenia (SPs). Current research suggests that the disrupted activation within and connectivity between regions of the cognitive control network contribute to disrupted proactive cognitive control; however, no study has examined these mechanisms using an AX Continuous Performance Test task in schizophrenia.
methodsTwenty-six SPs (17 male subjects; mean age 34.46 ± 8.77 years) and 28 healthy control participants (HCs; 16 male subjects; mean age 31.43 ± 7.23 years) underwent an electroencephalogram while performing the AX Continuous Performance Test. To examine the extent of activation and level of connectivity within the cognitive control network, power, intertrial phase clustering, and intersite phase clustering metrics were calculated and analyzed.
resultsSPs exhibited expected general decrements in behavioral performance relative to HCs and a more selective deficit in conditions requiring proactive cognitive control. Additionally, SPs exhibited deficits in midline theta power and connectivity during proactive cognitive control trials. Specifically, HCs exhibited significantly greater theta power for B cues relative to A cues, whereas SPs exhibited no significant differences between A- and B-cue theta power. Additionally, differential theta connectivity patterns were observed in SPs and HCs. Behavioral measures of proactive cognitive control predicted functional outcomes in SPs.
conclusionsThis study suggests that low-frequency midline theta activity is selectively disrupted during proactive cognitive control in SPs. The disrupted midline theta activity may reflect a failure of SPs to proactively recruit cognitive control processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.