ArticleJournal of the American Chemical Society2018
Divergent Synthesis of Pyrone Diterpenes via Radical Cross Coupling.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
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Who cites it
27 citing papers in PubMed, 95 citations in OpenAlex.
- Decarboxylative alkylation of alkenes.Nature · 2026Article
- Catalyst-Free Gas-Phase Synthesis of Pyrones via Thermally Induced Aldol Condensation of Acetoacetate Derivatives Using GC-MS.ACS omega · 2026Article
- Total Synthesis of Dactyloquinone A and Spiroetherone A via a Metal-Hydride Hydrogen Atom Transfer (MHAT) Process and a Quinol-Enedione Rearrangement.Angewandte Chemie (International ed. in English) · 2025Article
- Article
- Steglich esterification: A versatile synthetic approach toward the synthesis of natural products, their analogues/derivatives.Heliyon · 2024Article
- Mechanisms for radical reactions initiating fromBeilstein journal of organic chemistry · 2024Article
- Combining the best of both worlds: radical-based divergent total synthesis.Beilstein journal of organic chemistry · 2023Review
- Electro-Synthesis of Organic Compounds with Heterogeneous Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Photoredox-Catalyzed Oxidation of Anions for the Atom-Economical Hydro-, Amido-, and Dialkylation of Alkenes.The Journal of organic chemistry · 2022Article
- Evolution towards green radical generation in total synthesis.Chemical Society reviews · 2021Review
- Tailored cobalt-salen complexes enable electrocatalytic intramolecular allylic C-H functionalizations.Nature communications · 2021Article
- Ideality in Context: Motivations for Total Synthesis.Accounts of chemical research · 2021Article
- Review
- Electroreductive Carbofunctionalization of Alkenes with Alkyl Bromides via a Radical-Polar Crossover Mechanism.Journal of the American Chemical Society · 2020Article
- Transition Metal-Mediated C-C Single Bond Cleavage: Making the Cut in Total Synthesis.Angewandte Chemie (International ed. in English) · 2020Review
- Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes.Nature chemistry · 2020Article
- Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.Nature communications · 2020Article
- Catalyzing Electrosynthesis: A Homogeneous Electrocatalytic Approach to Reaction Discovery.Accounts of chemical research · 2020Review
- A Survival Guide for the "Electro-curious".Accounts of chemical research · 2020Review
- Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.Journal of medicinal chemistry · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
A divergent strategy for assembling pyrone diterpenes is presented. Capitalizing on the unique stereo- and chemoselectivity features of radical-based chemistry, the core decalin of these structures is efficiently forged using an electrochemically assisted oxidative radical polycyclization while key peripheral substituents are appended using decarboxylative radical cross couplings. In this way, access to four natural products (subglutinols A/B, higginsianin A, and sesquicillin A) is achieved in a concise and stereocontrolled fashion that is modular and amenable to future medicinal chemistry explorations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.