Evidence map›Paper›PMID 29920989›Full record

ArticleBrain and behavior2018

Epineural adipose-derived stem cell injection in a sciatic rodent model.

Elisabeth A Kappos, Patricia Baenziger-Sieber, Mathias Tremp, Patricia E Engels, Sarah Thommen, Lima Sprenger, Robyn M Benz, Dirk J Schaefer, Stefan Schaeren, Daniel Felix Kalbermatten

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Adipose Tissue Uses in Peripheral Nerve Surgery.International journal of molecular sciences · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Elisabeth A KapposDepartment of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland.ORCID 0000-0003-4057-1951
Patricia Baenziger-SieberDepartment of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland.
Mathias TrempDepartment of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland.ORCID 0000-0001-6593-9690
Patricia E EngelsDepartment of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland.
Sarah ThommenBasel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
Lima SprengerDepartment of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland.
Robyn M BenzDepartment of Radiology, University Hospital Basel, Basel, Switzerland.
Dirk J SchaeferDepartment of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland.
Stefan SchaerenDepartment of Spinal Surgery, University Hospital of Basel, Basel, Switzerland.
Daniel Felix KalbermattenDepartment of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland.
University Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim was to evaluate the regenerative effect of epineural injection of rat ASCs (rASCs) in three different settings of acute and chronic compression in a rat sciatic nerve model.

methodsAcute compression (60 s) with a vessel clamp over a distance of 1 mm (group 1) or 10 mm (group 2), as well as chronic compression with a permanent remaining, nonabsorbable polymeric clip over a distance of 1 mm (group 3) was performed. Depending on the group, either 5 × 10

resultsThe rats in group 2 had a better function than those with group 1 at one and especially at 2 weeks. After 4 weeks however, almost all rats were close to a normal function. There was a similar Muscle Weight Ratio (MWR) after 2 weeks in all groups, whereas after 4 weeks, the MWR in group 3 was lower compared with group 1 and 2. Histomorphometric analysis showed a better myelination in group 1 & 2 compared to group 3 after 4 weeks. ASCs have a beneficial effect on myelin thickness (G-Ratio).

conclusionsWe successfully evaluated the regenerative effect of epineural injection of rASCs in three different settings of acute and chronic compression. However, there were no significant differences in outcomes between the ASC-treated groups and control groups.

Indexed as

AdipocytesAdult Stem CellsAnimalsConstrictionDisease Models, AnimalFemaleGaitInjectionsMuscle, SkeletalNerve Compression SyndromesNerve RegenerationOrgan SizePeripheral NervesRats, Sprague-DawleySciatic NerveSciatic Neuropathyadult stem cellsnerve compression syndromesnerve regenerationtissue engineeringtreatment outcome

Identifiers

PMID29920989
PMCPMC6043702
OpenAlexW2809603476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.