Evidence map›Paper›PMID 29920885›Full record

ArticleBipolar disorders2018

Comprehensive comparison of monotherapies for psychiatric hospitalization risk in bipolar disorders.

Anastasiya Nestsiarovich, Aurélien J Mazurie, Nathaniel G Hurwitz, Berit Kerner, Stuart J Nelson, Annette S Crisanti, Mauricio Tohen, Ronald L Krall, Douglas J Perkins, Christophe G Lambert

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bipolar disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02893371 (Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02893371 terminatednot on this map

Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies

TypeobservationalSponsorUniversity of New MexicoRan2016 to 2019Enrolled1,037,352ConditionsBipolar DisorderArmsLithium Carbonate, Lamotrigine, Valproic Acid, Oxcarbazepine, Carbamazepine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Anastasiya NestsiarovichCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID 0000-0002-5558-2381
Aurélien J MazurieTwoFoldChange Consulting, Bozeman, MT, USA.
Nathaniel G HurwitzNew Mexico Behavioral Health Institute, Las Vegas, NM, USA.
Berit KernerSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Stuart J NelsonUniversity of New Mexico Health Sciences Library and Informatics Center, Albuquerque, NM, USA.
Annette S CrisantiDepartment of Psychiatry & Behavioral Sciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Mauricio TohenDepartment of Psychiatry & Behavioral Sciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID 0000-0001-8049-4351
Ronald L KrallUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Douglas J PerkinsCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Christophe G LambertCenter for Global Health, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID 0000-0003-1994-2893
New Mexico Department of Health · USUniversity of New Mexico · USNew Mexico Highlands University · UST1D Exchange · USUniversity of Pittsburgh · USWitten/Herdecke University · DE

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
NCATS NIH HHS UL1 TR001449
6 · The paper itself

Abstract

objectivesThis study compared 29 drugs for risk of psychiatric hospitalization in bipolar disorders, addressing the evidence gap on the >50 drugs used by US patients for treatment.

methodsThe Truven Health Analytics MarketScan

resultsThree drugs were associated with significantly lower risk of psychiatric hospitalization than lithium: valproate (relative risk [RR] = 0.80, P = 3.20 × 10

conclusionsThis largest reported retrospective observational study on bipolar disorders pharmacotherapy to date demonstrates that the majority of patients end monotherapy within 2 months after treatment start. The risk of psychiatric hospitalization varied almost two-fold across individual medications. The data add to the evidence favoring lithium and mood stabilizer use in short-term bipolar disorder management. The findings that the dopaminergic drugs aripiprazole and bupropion had better outcomes than other members of their respective classes and that antidepressant outcomes may vary by baseline mood polarity merit further investigation.

Indexed as

AdultAnticonvulsantsAntidepressive AgentsAntimanic AgentsAntipsychotic AgentsBipolar DisorderFemaleHospitalizationHumansLithium CompoundsMaleMiddle AgedPsychotic DisordersRetrospective StudiesRiskAnticonvulsantsAntidepressive AgentsAntimanic AgentsAntipsychotic AgentsLithium Compoundsbipolar disordercomparative effectivenesscompeting risksdrughospitalizationschizoaffective

Identifiers

PMID29920885
PMCPMC6586061
OpenAlexW2808719256

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.