ArticleAddiction (Abingdon, England)2018
Cigarette consumption and biomarkers of nicotine exposure during pregnancy and postpartum.
Article in Addiction (Abingdon, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Development and Validation of a Novel Placental DNA Methylation Biomarker of Maternal Smoking during Pregnancy in the ECHO Program.Environmental health perspectives · 2024Trial
- Pregnancy-Induced Increases in the Nicotine Metabolite Ratio: Examining Changes During Antepartum and Postpartum.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Trial
- The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes.International journal of cancer · 2025Article
- Article
- Risk Identification in Perinatal Health Care Settings via Technology-Based Recruitment Methods: Comparative Study.JMIR formative research · 2024Article
- Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers.Pharmacology research & perspectives · 2023Article
- Robust tobacco smoking self-report in two cohorts: pregnant women or men and women living with or without HIV.Scientific reports · 2023Article
- Measurement of cigarette smoking: Comparisons of global self-report, returned cigarette filters, and ecological momentary assessment.Experimental and clinical psychopharmacology · 2022Article
- The effects of prenatal nicotine and THC E-cigarette exposure on motor development in rats.Psychopharmacology · 2022Article
- Maternal nicotine metabolism moderates the impact of maternal cigarette smoking on infant birth weight: A Collaborative Perinatal Project investigation.Drug and alcohol dependence · 2022Article
- Use of electronic nicotine delivery systems (ENDS) among U.S. women of reproductive age: Prevalence, reported reasons for use, and toxin exposure.Preventive medicine · 2021Article
- High Rates of Menthol Cigarette Use Among Pregnant Smokers: Preliminary Findings and Call for Future Research.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Intensive Behavioural and Pharmacological Treatment for Tobacco Dependence in Pregnant Women with Complex Psychosocial Challenges: A Case Report.International journal of environmental research and public health · 2020Article
- A review of tobacco regulatory science research on vulnerable populations.Preventive medicine · 2019Review
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Abstract
BACKGROUND AND
aimsSmokers can regulate their nicotine intake by altering the number of cigarettes smoked per day (CPD) and their smoking intensity. The current study aimed to compare the utility of self-reported CPD, total nicotine equivalents (TNE) and urinary cotinine to estimate nicotine intake during pregnancy.
designLongitudinal smoking behavior and biomarker data were collected at early pregnancy, late pregnancy and at postpartum as part of a smoking cessation trial to examine voucher-based incentives for decreasing smoking.
settingObstetric practices in Burlington, Vermont, United States.
participantsA subset of participants (n = 47) from the parent trial, recruited between December 2006 and June 2012, who provided a urine sample at each assessment during early pregnancy, late pregnancy and postpartum. MEASUREMENTS: Smoking was assessed using self-reported CPD, TNE, TNE/CPD and urinary cotinine.
findingsPregnant smokers reported smoking 10.4 CPD at early pregnancy, 7.2 CPD at late pregnancy (a 31% reduction at late pregnancy, P = 0.001) and 8.6 CPD at postpartum (a 19% increase from late pregnancy, P = 0.08). TNE exposure was 41% (P = 0.07) and 48% (P = 0.03) lower at early and late pregnancy, respectively, compared to postpartum. TNE/CPD was on average 167% higher at late pregnancy compared to early pregnancy (P = 0.01) and remained high at postpartum, where it was 111% higher compared to early pregnancy (P = 0.007). Uriniary cotinine underestimated nicotine intake by 55% during early pregnancy and by 65% during late pregnancy compared to postpartum (P
conclusionsNeither cigarettes smoked per day (CPD) nor cotinine provides an accurate estimate of nicotine exposure during pregnancy. CPD underestimates nicotine intake substantially due to under-reporting and/or higher intensity of smoking, while cotinine underestimates nicotine intake markedly due to accelerated nicotine (and cotinine) metabolism during pregnancy.
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