Evidence map›Paper›PMID 29920638›Full record

ArticleAmerican journal of perinatology2018

Respiratory Syncytial Virus Hospitalizations among U.S. Preterm Infants Compared with Term Infants Before and After the 2014 American Academy of Pediatrics Guidance on Immunoprophylaxis: 2012-2016.

Mitchell Goldstein, Leonard R Krilov, Jaime Fergie, Kimmie K McLaurin, Sally W Wade, David Diakun, Gregory M Lenhart, Adam Bloomfield, Amanda M Kong

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of perinatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mitchell GoldsteinDivision of Neonatal Medicine, Loma Linda University Children's Hospital, Loma Linda, California.
Leonard R KrilovPediatric Infectious Diseases, Children's Medical Center, NYU Winthrop, Mineola, New York.
Jaime FergieDepartment of Pediatric Infectious Disease, Driscoll Children's Hospital, Corpus Christi, Texas.
Kimmie K McLaurinAstraZeneca, Gaithersburg, Maryland.
Sally W WadeWade Outcomes Research and Consulting, Salt Lake City, Utah.
David DiakunTruven Health Analytics, an IBM Company, Cambridge, Massachusetts.
Gregory M LenhartTruven Health Analytics, an IBM Company, Cambridge, Massachusetts.
Adam BloomfieldAstraZeneca, Gaithersburg, Maryland.
Amanda M KongTruven Health Analytics, an IBM Company, Cambridge, Massachusetts.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to compare risk for respiratory syncytial virus (RSV) hospitalizations (RSVH) for preterm infants 29 to 34 weeks gestational age (wGA) versus term infants before and after 2014 guidance changes for immunoprophylaxis (IP), using data from the 2012 to 2016 RSV seasons. STUDY

designUsing commercial and Medicaid claims databases, infants born between July 1, 2011 and June 30, 2016 were categorized as preterm or term. RSVH during the RSV season (November-March) were identified for infants aged <6 months and rate ratios (RRs) for hospitalization comparing preterm and term infants were calculated. Difference-in-difference models were fit to evaluate the changes in hospitalization risks in preterm versus term infants from 2012 to 2014 seasons to 2014 to 2016 seasons.

resultsIn all seasons, preterm infants had higher RSVH rates than term infants. Seasonal RRs prior to the guidance change for preterm wGA categories versus term infants ranged from 1.6 to 3.4. After the guidance change, the seasonal RRs ranged from 2.6 to 5.6. In 2014 to 2016, the risk associated with prematurity of 29 to 34 wGA versus term was significantly higher than in 2012 to 2014 (

conclusionIn infants aged <6 months, the risk for RSVH for infants 29 to 34 wGA compared with term infants increased significantly after the RSV IP recommendations became more restrictive.

Indexed as

Hospital CostsInfant, PrematureAntiviral AgentsDatabases, FactualFemaleGestational AgeHealth Care CostsHospitalizationHumansInfantInfant, NewbornIntensive Care Units, PediatricMaleMedicaidPalivizumabPractice Guidelines as TopicAntiviral AgentsPalivizumab

Identifiers

PMID29920638
PMCPMC6260117

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.