Evidence map›Paper›PMID 29920544›Full record

ArticlePloS one2018

Methyl dihydrojasmonate and lilial are the constituents with an "off-label" insect repellence in perfumes.

Fangfang Zeng, Pingxi Xu, Kaiming Tan, Paulo H G Zarbin, Walter S Leal

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Applications of Ene-Reductases in the Synthesis of Flavors and Fragrances.Journal of agricultural and food chemistry · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Olfaction in Anopheles mosquitoes.Chemical senses · 2021
    Review
  9. Article
  10. Article
  11. Mediation of Potato-Potato Cyst Nematode,Frontiers in plant science · 2020
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Fangfang ZengDepartment of Molecular and Cellular Biology, University of California-Davis, Davis, CA, United States of America.
Pingxi XuDepartment of Molecular and Cellular Biology, University of California-Davis, Davis, CA, United States of America.
Kaiming TanDepartment of Molecular and Cellular Biology, University of California-Davis, Davis, CA, United States of America.
Paulo H G ZarbinDepartamento de Química, Universidade Federal do Paraná, Laboratório de Ecologia Química e Síntese Orgânica, Curitiba-PR, Brazil.
Walter S LealDepartment of Molecular and Cellular Biology, University of California-Davis, Davis, CA, United States of America.ORCID 0000-0002-6800-1240
University of California, Davis · USUniversidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insect repellents are widely used to fend off nuisance mosquitoes and, more importantly, to reduce or eliminate mosquito bites in areas where viruses and other vector-borne diseases are circulating. Synthesized more than six decades ago, DEET is the most widely used insect repellent. Plant-derived compounds are used in a plethora of commercial formulations and natural recipes to repel mosquitoes. They are also used as fragrances. We analysed Bombshell® to identify the constituent(s) eliciting a previously reported "off- label" repellence activity. The two major fragrance ingredients in Bombshell, i.e., methyl dihydrojasmonate and lilial, demonstrated strong repellence against the southern house mosquito, Culex quinquefasciatus, in laboratory assays. Both compounds activated a previously identified DEET-sensitive odorant receptor, CquiOR136. These compounds were also major constituents of Ivanka Trump eau de parfum. The methyl dihydrojasmonate content was higher in the Ivanka Trump perfume than in Bombshell, the reverse being true for lilial. Both Bombshell and Ivanka Trump eaux de parfums retained activity for as long as 6 hours in laboratory assays. Although wearing these perfumes may repel nuisance mosquitoes, their use as "off-label" repellents against infected mosquitoes is not recommended.

Indexed as

AldehydesAnimalsCulicidaeCyclopentanesDEETHumansInsect Bites and StingsInsect RepellentsOdorantsAldehydesCyclopentanesDEETInsect Repellentslilialmethyldihydrojasmonate

Identifiers

PMID29920544
PMCPMC6007898
OpenAlexW2808974124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.