Evidence map›Paper›PMID 29920521›Full record

Trial reportPloS one2018

Low-level laser treatment applied at auriculotherapy points to reduce postoperative pain in third molar surgery: A randomized, controlled, single-blinded study.

Hélio Sampaio-Filho, Sandra Kalil Bussadori, Marcela Leticia Leal Gonçalves, Daniela de Fátima Teixeira da Silva, Maria Cristina Borsatto, Isabel Peixoto Tortamano, Priscila Larcher Longo, Christiane Pavani, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari and 1 more

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02657174 phase4unknown statusnot on this map

Effectiveness of Low Level Laser at the Auriculotherapy Points, in Reducing Postoperative Pain in Third Molar Surgery

TypeinterventionalSponsorUniversity of Nove de JulhoRan2015 to 2017Enrolled80ConditionsPainArmslow level laser in auricular acupuncture points, low level laser device off in auricular acupuncture points
NCT07125404 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effectiveness of Low-Level Laser Auriculotherapy in the Treatment of Myogenic Temporomandibular Disorders and Anxiety: A Randomized Clinical Trial

TypeinterventionalSponsorQuiropraxia y EquilibrioRan2025 to 2026Enrolled32ConditionsTemporomandibular Disorder, Anxiety StateArmsLow-level laser auriculotherapy (LLLT-AT), Sham Low-level laser auriculotherapy (sham LLLT-AT), Myofascial release
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hélio Sampaio-FilhoPostgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.
Sandra Kalil BussadoriPostgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.
Marcela Leticia Leal GonçalvesPostgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.
Daniela de Fátima Teixeira da SilvaPostgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.
Maria Cristina BorsattoDepartment of Odontopediatrics Clinic, São Paulo University, Ribeirão Preto, SP, Brazil.
Isabel Peixoto TortamanoDepartment of Estomatology, São Paulo University, São Paulo, SP, Brazil.
Priscila Larcher LongoDepartment of Microbiology, São Paulo University, São Paulo, SP, Brazil.
Christiane PavaniPostgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.
Kristianne Porta Santos FernandesPostgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.
Raquel Agnelli Mesquita-FerrariPostgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.
Anna Carolina Ratto Tempestini HorlianaPostgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, UNINOVE, São Paulo, SP, Brazil.ORCID 0000-0003-3476-9064
Universidade Nove de Julho · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEvaluate the effectiveness of LLL (Low level laser therapy) in auriculotherapy points for pain reduction following lower third molar extractions. STUDY

designRandomized, controlled, single-blinded study.

methodsEighty-four bilateral, symmetrical third molar surgeries were performed in 42 healthy patients using a split-mouth design. In the immediate postoperative period, each side was randomly treated in a single-blind method with an LLL at the auriculotherapy points or simulation of its use (contralateral side) over a 21-day interval. This protocol was repeated 24 and 48 hours after surgery. All patients used the same analgesic (paracetamol) but only in case of pain. The primary variable was postoperative pain according to the visual analogue scale, and the secondary variables were mouth opening, edema, local temperature, dysphagia, and the presence of infection (systemic temperature, lymphadenopathy). These variables were evaluated at baseline and at 24 hours, 48 hours and seven days after surgery. Adverse effects were recorded and reported.

resultsThere was no difference between the groups in relation to any of the evaluated parameters (p>0.05).

conclusionFor this experimental model, application of a low-intensity laser at auriculotherapy points did not prevent postoperative pain following lower third molar surgery.

trial registrationThis trial is registered at ClinicalTrials.gov; the registration number is NCT02657174 and the Unique Protocol ID number is 1.100.869. (https://register.clinicaltrials.gov/prs/app/template/EditRecord.vm?epmode=View&listmode=Edit&uid=U0002BEY&ts=11&sid=S0006026&cx=6g4wff).

Indexed as

AuriculotherapyLow-Level Light TherapyAdultFemaleHumansMaleMolar, ThirdPostoperative PainSingle-Blind MethodTooth Extraction

Identifiers

PMID29920521
PMCPMC6007895
OpenAlexW2809082989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.