ArticleJournal of innate immunity2018
Short-Form Bomanins Mediate Humoral Immunity in Drosophila.
Article in Journal of innate immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 82 citations in OpenAlex.
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- Distinct Bomanins at the Drosophila 55C locus function in resistance and resilience to infections.EMBO reports · 2026Article
- A binary-distributed effector modulates fungal host preference for drosophilids by targeting a lineage-specific immune factor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Functional characterization of Paillotin: an immune peptide regulated by the Immune deficiency (Imd) pathway with pathogen-specific roles inProceedings. Biological sciences · 2025Article
- Evolution of resistance and disease tolerance mechanisms to oral bacterial infection inOpen biology · 2025Article
- Escherichia coli and Micrococcus luteus Activate the CG45045 Gene in Drosophila S2 Cell Line.Doklady. Biochemistry and biophysics · 2024Article
- An unusual Toll/MyD88-mediatedFly · 2024Article
- Pygo-F773W Mutation Reveals Novel Functions beyond Wnt Signaling inInternational journal of molecular sciences · 2024Article
- The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization.Cellular and molecular life sciences : CMLS · 2024Article
- Transcriptomic Insights into Host Metabolism and Immunity Changes after Parasitization byInsects · 2024Article
- Lysine-36 of Drosophila histone H3.3 supports adult longevity.G3 (Bethesda, Md.) · 2024Article
- The Lifespan ofInsects · 2024Article
- The utility ofFrontiers in immunology · 2024Review
- Lysine-36 ofbioRxiv : the preprint server for biology · 2023Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Bomanins (Boms) are a family of a dozen secreted peptides that mediate the innate immune response governed by the Drosophila Toll receptor. We recently showed that deleting a cluster of 10 Bom genes blocks Toll-mediated defenses against a range of fungi and gram-positive bacteria. Here, we characterize the activity of individual Bom family members. We provide evidence that the Boms overlap in function and that a single Bom gene encoding a mature peptide of just 16 amino acids can act largely or entirely independent of other family members to provide phenotypic rescue in vivo. We further demonstrate that the Boms function in Drosophila humoral immunity, mediating the killing of the fungal pathogen Candida glabrata in an in vitro assay of cell-free hemolymph. In addition, we find that the level of antifungal activity both in vivo and in vitro is linked to the level of Bom gene expression. Although Toll dictates expression of the antimicrobial peptides (AMPs) drosomycin and metchnikowin, we find no evidence that Boms act by modifying the expression of the mature forms of these antifungal AMPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.