Evidence map›Paper›PMID 29920286›Full record

ArticleChemico-biological interactions2018

The inhibition, reactivation and mechanism of VX-, sarin-, fluoro-VX and fluoro-sarin surrogates following their interaction with HuAChE and HuBuChE.

Chih-Kai Chao, Narayanaganesh Balasubramanian, John M Gerdes, Charles M Thompson

Abstract read
In one paragraph

Article in Chemico-biological interactions, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Chemical, Physical, and Toxicological Properties of V-Agents.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Review
  5. Divergent synthesis of organophosphate [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2019
    Article
  6. Radiosynthesis of O-(1-[Journal of labelled compounds & radiopharmaceuticals · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chih-Kai ChaoDepartment of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT, 59812, United States.
Narayanaganesh BalasubramanianDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT, 59717, United States.
John M GerdesDepartment of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT, 59812, United States.
Charles M ThompsonDepartment of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT, 59812, United States. Electronic address: chuck.thompson@mso.umt.edu.

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Jeffrey Good · 2012 to 2026
$60.0M
Molecular Imaging of Chemical Threats and CountermeasuresU01NS092495 · NINDS · UNIVERSITY OF MONTANA · PI GERDES, JOHN M, THOMPSON, CHARLES MARK · 2015 to 2019
$3.9M
NIGMS NIH HHS P20 GM103474NINDS NIH HHS U01 NS092495
6 · The paper itself

Abstract

In this study, the mechanisms of HuAChE and HuBChE inhibition by Me-P(O) (OPNP) (OR) [PNP = p-nitrophenyl; R = CH

Indexed as

AcetylcholinesteraseButyrylcholinesteraseChemical Warfare AgentsCholinesterase ReactivatorsEnzyme ActivationFluorescenceHumansKineticsOrganophosphorus CompoundsOrganothiophosphorus CompoundsParaoxonSarinSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAcetylcholinesteraseButyrylcholinesteraseChemical Warfare AgentsCholinesterase ReactivatorsOrganophosphorus CompoundsOrganothiophosphorus CompoundsParaoxonSarinVX-agent

Identifiers

PMID29920286
PMCPMC6061941

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.